血栓弹力图评价血小板花生四烯酸途径抑制率对血凝块形成的影响

《血栓弹力图评价血小板花生四烯酸途径抑制率对血凝块形成的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、军医进修学院学报·430·JChinesePLAPostgradMedSchMay2011，32（5）血栓弹力图评价血小板花生四烯酸途径抑制率对血凝块形成的影响1121111黎金庆，周合冰，郭金成，单志娟，张　娟，曾　惠，付晨晓12通州区潞河医院，北京　101149　　血液科；心内科摘要：目的了解血小板花生四烯酸途径抑制率对血凝块形成的影响及其与ADP受体途径抑制率的关系。方法联用阿司匹林和氯吡格雷的急性冠脉综合征80例，血栓弹力图测定血小板抑制率和花生四烯酸通道的α角、K时间、MA、TMA。结果

2、花生四烯酸途径抑制率为(81.7±20.7)%，ADP受体抑制率为(65.9±25.3)%，α角为(48.2±15.9)°，MA为(20.8±14.2)mm，TMA为(13.8±7.5)min。随花生四烯酸途径抑制率增高，α角缩小，MA降低，TMA缩短，ADP受体抑制率增高(P<0.05)，K时间延长并且无K时间病例增多。结论抑制血小板花生四烯酸途径不利于血凝块形成，随抑制率增高，血凝块形成减慢、强度变小；二条途径抑制率呈正相关。关键词：血栓弹力描记术；阿司匹林；氯吡格雷中图分类号：R973　　文

3、献标识码：A　　文章编号：1005-1139(2011)05-0430-03　　DOI:CNKI:11-3275/R.20101124.1128.001网络出版时间：2010-11-2411:28:12　　　网络出版地址：http://www.cnki.net/kcms/detail/11.3275.r.20101124.1128.001.htmlInhibitoryeffectofarachidonicacidpathwayinplateletsonclotformationassessedby

4、thromboelastography1121111LIJin-qing,ZHOUHe-bing,GUOJin-cheng,SHANZhi-juan,ZHANGJuan,ZENGHui,FUChen-xiao12DepartmentofHematology;DepartmentofCardiologyBeijingLuheHospital,Beijing101149,ChinaThefirstauthor:LIJin-qing.Email:mjmljqmjmljq@163.comAbstract:

5、ObjectiveTostudytheinhibitoryeffectofarachidonicacidpathwayinplateletsonclotformationanditscorrelationwithADPreceptorinhibition.MethodsEightypatientswithacutecoronarysyndromeweretreatedwithaspirin(100mg)incombinationwithclopidogrel(75mg)daily.Inhibito

6、ryrateofarachidonicacidpathwayandADPreceptorpathwayinplateletsweredetectedbythromboelastography.Thefollowingvariblesofarachidonicacidchannelwerealsorecorded:αangle,Ktime,maximumamplitude(MA)andtimetoMA(TMA).ResultsTheinhibitoryrateofarachidonicacidpat

7、hwayandADPreceptorpathwaywas81.7%±20.7%and65.9%±25.3%,respectively.Theαangle,MAandTMAwere(48.2±15.9)°,(20.8±14.2)mmand(13.8±7.5)min,respectively.Theαanglebecamesmaller,theMAdecreasedandtheTMAbecameshorterwiththeincreasinginhibitoryrateofarachidonicaci

8、dpathway(P<0.05).ThenumberofcaseshavingnoKtimewasincreasedwhentheKtimebecamelonger.ConclusionInhibitionofarachidonicacidpathwayinplateletsisnotfavorableforclotformation.Thespeedandstrengthofclotformationdecreasewiththeincreasinginhibitoryrateo