合并心肌损伤的窒息新生儿血浆心肌营养素-1及糖原磷酸化酶同工酶脑型的测定及临床意义.pdf

《合并心肌损伤的窒息新生儿血浆心肌营养素-1及糖原磷酸化酶同工酶脑型的测定及临床意义.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、·86·实用临床医学2014年第15卷第6期PraaicalClinicalMedicine。2014．Vol15．No6合并心肌损伤的窒息新生儿血浆心肌营养素一1及糖原磷酸化酶同工酶脑型的测定及临床意义黎日保．李彦甫(吴川市妇幼保健院新生儿科，广东吴川524500)摘要：目的探讨合并心肌损伤的窒息新生儿血浆心肌营养素一1fcaMiotrophin一1．CT一11以及糖原磷酸化酶同工酶脑型(glycogenphosphorylaseisoenzymeBB，GPBB)的变化及其临床意义。方法选择72例

2、合并心肌损伤窒息新生儿为试验组【其中轻度窒息39例(轻度窒息组)，重度窒息33例(重度窒息组)1，32例健康新生儿为对照组，采用酶联免疫吸附法(ELISA)~定血浆GPBB、CT_1水平，并分析血浆GPBB、CT-1水平与窒息程度的关系。结果试验组血浆GPBB、Crr-1水平均明显高于对照组(均P

3、CT一1水平呈正相关关系(r=0．547，P

4、eofPlasmaCardiotrophin-1andGlycogenPhosphorylaseIsoenzymeBBinAsphyxiatedNewbornInfantswithMyocardialInjuryLIRi-bao，LIYan-fu(DepartmentofNeonatologyWuchuanMaternalandChildHealthCareCenter,Wuchuan524500，China)ABSTRACT：ObjectiveToobservethechangesinplasma

5、cardiotrophin一1(CT一1)andglycogenphosphorylaseisoenzymeBB(GPBB)andtheirclinicalsignificanceinasphyxiatednewborninfantswithmyocardialinjury．MethodsThelevelsofplasmaCT-1andGPBBweredetectedbyELISAin72asphyxiatednewborninfantswithmyocardialinjury(experiment

6、algroup)and32healthynewborns(controlgroup)．Inaddition，infantsinexperimentalgroupwerefurtherdividedintomildasphyxiagroup(n=39)andsevereasphyxiagroup(n=33)．TherelationshipsofasphyxiadegreetoCT-1andGPBBlevelswereanalyzed．ResultsComparedwithcontrolgroup，le

7、velsofGPBBandCT一1significantlydecreasedinexperimentalgroup(P<0．05)．Comparedwithmildasphyxiagroup，levelsofGPBBandCT-1significantlyincreasedinsevereasphyxiagroup．ThelevelsofplasmaGPBBandCT-1werenegativelycorrelatedwiththedegreeofasphyxia(r=-0．519andr=-0．

8、527，respectively，P<0．05)．Moreover，GPBBlevelswerepositivelycorrelatedwithCT-1levels(r=0．547，P<0．05)．ConclusionThelevelsofplasmaGPBBandCT一1increaseobviouslyandarenegativelycorelatedwiththedegreeof收稿日期：2014—03—10作者简介：黎日保(1977一)，男，本科，主治医师，主