非瓣膜病房颤患者血清尿酸和超敏C反应蛋白水平的变化.pdf

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1、论著China&ForeignMedicalTreatment口—■■固■●警—_非瓣膜病房颤患者血清尿酸和超敏c反应蛋白水平的变化郭瑞霞赵志勇济源市人民医院，河南济源459000【摘要】目的探讨非瓣膜病房颤患者血清尿酸(uA)及超敏C反应蛋白(hs—CRP)水平的变化，并探讨其临床意义。方法入选2012年12月一20l3年6月该院心内科住院诊断为非瓣膜病房颤患者108例，持续性房颤50例，阵发性房颤58例，对照组为同期门诊体检窦性心律、既往无房颤病史患者50例作为对照组。测定血清uA、hs—CRP等相关指标，

2、比较各组间血清中uA、hs—CRP水平的变化及两者之间的相关关系。结果房颤组血清UA、hs—CRP水平均高于对照组，且持续性房颤组高于阵发性房颤组，差异有统计学意义(P<0．05)。相关分析显示两者呈正相关。结论血清uA、hs—CRP水平的升高参与了房颤的发生及维持。【关键词】房颤；尿酸；超敏c反应蛋白【中图分类号】R589．7【文献标识码】A【文章编号】1674一O742【2014)04(c)一OO01一O3TheChangeofSerumUricAcidandHypersensitiveC-reactive

3、ProteininNonvalvularAtrialFibrillationGUORu~mlZHA0~／yongThePeople"sHospitalofJiyuanCity，Jiyuan，HenanProvince，459000，China[Abstract]ObjectiveToexplorethechangeandclinicalsignificanceofserumuricacid(UA)andhypersensitiveC—reactivepro—tein(hs-CRP)innonvalvularat

4、rialfibrillation．Methods108casesofpatientsadmittedinCardiovascularDepartmentofThePeo-pie'sHospitalofJiyuanCityanddiagnosedasnonvalvularatrialfibrillationfromDecember，2012toJune，2013wereenrolled，in-cluding50casesofpersistentatrialfibrillation，and58casesofparo

5、xysmalatrialfibrillation．50casesofpatientswithsinusrhythmandwithoutthehistoryofatrialfibrillationunderwentphysicalexaminationintheoutpatientduringthesameperiodWel[~selectedasthecontrolgroup．ThelevelsofserumUA．hs-CRPandotherrelatedindicatorsweremeasured．Thech

6、angeofserumUA．hs—CRPandtherelationbetweenthetwowerecomparedbetweenthegroups．ResultsTheserumleyelsofUAandhs-CRPoftheatrialfibrillationgroupwerehigherthanthoseofthecontrolgroup，evenmore，thoseofthepersistentatrialfibrillationgroupwerehigherthanthoseoftheparoxys

7、malatrialfibrillationgroup，thediferenceswerestatisticallysignificant(P<0．05)．RelationanalysisshowedthattheserumlevelofuricacidandhypersensitiveC-reactiveproteinwerepositivelycorrelated．ConclusionTheincreasedserumUAandhs—CRPwereinvolvedintheoccurrenceandmaint

8、enanceofatrialfibrillation．[Keywords]AtrialFibrillation；UricAcid；HypersensitiveC-reactiveProtein，房颤是临床常见的心律失常之一。但房颤的发病机制尚未酸(UA)是氧化损伤的一种标志物[31。该研究为探讨房颤患者血清完全明确。近年来相关研究【1】表明炎症和氧化应激作为始发因uA及超敏c反应蛋白(