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时间:2020-04-04
《宫颈上皮内瘤变的早期诊断方法的临床评价.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、宫颈上皮内瘤变的早期诊断方法的临床评价【关键词】宫颈上皮内瘤变【摘要】li的探讨细胞学筛查、阴道镜下多点活检以及宫颈锥切在宫颈上皮内瘤变的诊断价值和相互关系。方法木文对12()例因宫颈细胞学筛杏异常而进行阴道镜下多点活检以及宫颈锥切的病理结果进行冋顾性分析。结果120例患者经细胞学筛查后,发现ASCUS23.8%,低度上皮内瘤变(LSIL)以下的病例占38%,高度上皮内瘤变(HSIL)以上的占62%;经阴道镜下多点活检后,CINI以下的病例占17%,CINII以上的占85%,经阴道镜下多点活检后发现CINII以上病
2、例的阳性率显著高于细胞学(PV0.05),二者符合率67%;经宫颈锥切后,CINII以下的病例占42.5%,高于阴道镜下活检(32.5%),CINIII以上的病例占57.5%,低于阴道镜下多点活检(67.5%),二者差异有显著性(P<0.01),二者符合率为81.7%。20例ASCUS经阴道镜下多点活检及锥切后,CTNI以上的病例rS99.9%,CINII以上的病例占65%。HPV感染三种检杳结果不一致,阴道镜下多点活检后阳性检出率显著高于细胞学以及锥切结果,茅异有显著性(PvO.05)。纟轮细胞学筛查结果界常,经
3、阴道镜下多点活检及宫颈锥切示,CINTI和CINIIT或CIS以及早期浸润癌或癌的检出率显著增加,阴道镜下多点活检与宫颈锥切具有较好的相关性,由于锥切取材方面的优势,可避免仅根据阴道镜下多点活检结果所致的干预错误的发生,同时为进一步干预提供组织学依据。ASCUS的病例建议及时行阴道镜下多点活检,木组ASCUS病例屮CINII以上的病例占65%。对于HPV感染率,三者结果不一•致,如结合HPV-DNA的检测有利于提高宫颈癌前病变的筛查的准确率。关键词宫颈上皮内瘤变宫颈癌细胞学检杳阴道镜宫颈锥切人类乳头状病毒vPsty
4、le="TEXT-INDENT:24px"align=center>ClinicalevaluationonearlydiagnosingmethodsforcervicalintraepithelialneoplasmaJinLi,HuangHuifang,WangYoufang,etal.5、ter>DepartmentofObstetricsandGynecology,PekingUnionMedicalCollegeHospital,PekingUnionMedicalCollege,ChineseAcademyofMedicalScience,Beijing100730.[Abstract]ObjectiveTodescribethevalueofcytologicalscreentesting,colpscopicmultiplebiopsiesandcervicalconizationondi6、agnosiscervicalintraepithelialneoplasm(CIN)andtherelationsamongthem.Methods120caseswithabnormalcytologicalscreentestresultsornormalbuthighlysuspectedabnormalityinclinicsareanalyzedretrospectivelyafterbiopsiesundercolpscopyandconization.ResultsAmongthe120casess7、creenedbycytologicaltests,16.7%werefoundwithASCUS,33.0%withLSILorlessand67%withHSILorevencancer.Therewas85%withCINIIorhigherafterbiopsiesundercolpscopy,whichwassignifcantlyhigherthanHSILwithP<0.05.Theco-incideneerateofcytologicalscreentestsandbiopsiesundercopl8、scopywas67%.Basedonthepathologicalrsultsofbiopsiesundercolposcopy,patientswereconed.Thepathologicalresultsshowedthat42.5%patientswerewithCINIIorlessand57.5%>withCINlIIorhigher,whic
5、ter>DepartmentofObstetricsandGynecology,PekingUnionMedicalCollegeHospital,PekingUnionMedicalCollege,ChineseAcademyofMedicalScience,Beijing100730.[Abstract]ObjectiveTodescribethevalueofcytologicalscreentesting,colpscopicmultiplebiopsiesandcervicalconizationondi
6、agnosiscervicalintraepithelialneoplasm(CIN)andtherelationsamongthem.Methods120caseswithabnormalcytologicalscreentestresultsornormalbuthighlysuspectedabnormalityinclinicsareanalyzedretrospectivelyafterbiopsiesundercolpscopyandconization.ResultsAmongthe120casess
7、creenedbycytologicaltests,16.7%werefoundwithASCUS,33.0%withLSILorlessand67%withHSILorevencancer.Therewas85%withCINIIorhigherafterbiopsiesundercolpscopy,whichwassignifcantlyhigherthanHSILwithP<0.05.Theco-incideneerateofcytologicalscreentestsandbiopsiesundercopl
8、scopywas67%.Basedonthepathologicalrsultsofbiopsiesundercolposcopy,patientswereconed.Thepathologicalresultsshowedthat42.5%patientswerewithCINIIorlessand57.5%>withCINlIIorhigher,whic
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