黄芪建中汤对脾虚型慢性萎缩性胃炎大鼠消化系统的影响

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1、万方数据CHINESEJOURNALoFANATOMYV01．30No．62007解剖学杂志2007年第30卷第6期黄芪建中汤对脾虚型慢性萎缩性胃炎大鼠消化系统的影响。刘旺根1蒋时红1(1河南中医学院解剖学与组织胚胎学学科，郑州王琦1王雪萍1昊景兰2450003；2郑州大学组织学与胚胎学教研室，郑州450052)、摘要目的：探讨黄芪建中汤对慢性萎缩性胃炎(CAG)的疗效及其机制。方法：将24只Wismr大鼠随机分为正常对照组(C)、CAG组、维酶素(V)组、黄芪建中汤(HJD)组，观察大鼠胃黏膜、空肠黏膜、肝和胰外分泌部组织中的糖

2、原含量、SDH、LDH、ANAE和ACP活性。结果：与正常大鼠相比，CAG组大鼠一般状况欠佳，体质量明显减轻；大鼠胃黏膜萎缩、变薄，胃黏膜炎症程度积分和胃黏膜糜烂程度积分明显升高，而胃黏膜厚度和腺管总长度明显降低；空肠和肝也呈现出不同程度的病理学改变；大鼠上述脏器的糖原含量、SDH、ANAE、ACP和LDH活性多数显著降低；经黄芪建中汤治疗21d后，上述指标明显改善并明显优于维酶素组。结论：脾虚型CAG状态下，机体存在多脏器代谢紊乱，黄芪建中汤对之有良好的复健作用，其疗效显著优于维酶素。关键词黄芪建中汤；慢性萎缩性胃炎；脾虚；组织

3、代谢；大鼠EffectsofHuangqiJianzhongDecoctiononthedigestivesystemofratwithchronicatrophicgastritiswithsyndromeofspleendeficiency+LiuWanggenl，JiangShihon91，WangQil，WangXuepin91。WuJinglanz(1DepartmentofHistologyandEmbyology，HenanCollegeofTraditionalChineseMedicine，Zhengzhou45

4、0003，China；2DepartmentofHistologyandEmbryology，ZhengzhouUniversity，Zhengzhou450052，China)AbstractObjective．TostudythemechanismfortherapeuticeffectsofHuangqiJianzhongDecoction(HJD)onratmodelsofchronicatrophicgastritis(CAG)ofspleendeficiencytype．Methods：24Wistarratswere

5、randomlydividedintocontrol(C)group，CAGgroup，vitacoenzyme(V)groupandHJDgroup．SDH，LDH，ANAE，ACPandglyco-geninthestomachmncosa，junummucosa，liverandpancreasexocrinepartwereexaminedineachgrouprespective-lY．Results：ComparedwiththeCgroup。thebodyqualityinCAGgroupwasreducedmark

6、edlywithgeneralweakness．Thegastricmucosaebecameatrophyandthinnerwithobviouserosionandmoreinflammatorycells．Thestructuresofthejejunumandliveralsoweredestroyed．TheexpressionsofSDH，LDH，ANAE，ACPandglycogenwereweaker．Thereweresignificantdifferencesinallaboveparametersbetwe

7、entheCAGgroupandCgroup，andtheHJDgroupandVgroup．Conclusion：、7lmenchronicatrophicgastritis(CAG)withsyndromeofspleendeficiencyhappened，themetabolismisdisorderinseveralorgansasabove，whichcouldbeimprovedbyHJD．ThetherapeuticeffectsofHJDpredominatedovervitacoenzyme．KeywordsH

8、uangqiJianzhongDecoction；ch．ronicatrophicgastritis；syndromeofspleendeftciency；metabolism；rat现代中医研究认为慢性萎缩性胃炎(chronica—trophic