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时间:2017-12-08
《黄芪建中汤对脾虚型慢性萎缩性胃炎大鼠消化系统的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、万方数据CHINESEJOURNALoFANATOMYV01.30No.62007解剖学杂志2007年第30卷第6期黄芪建中汤对脾虚型慢性萎缩性胃炎大鼠消化系统的影响。刘旺根1蒋时红1(1河南中医学院解剖学与组织胚胎学学科,郑州王琦1王雪萍1昊景兰2450003;2郑州大学组织学与胚胎学教研室,郑州450052)、摘要目的:探讨黄芪建中汤对慢性萎缩性胃炎(CAG)的疗效及其机制。方法:将24只Wismr大鼠随机分为正常对照组(C)、CAG组、维酶素(V)组、黄芪建中汤(HJD)组,观察大鼠胃黏膜、空肠黏膜、肝和胰外分泌部组织中的糖
2、原含量、SDH、LDH、ANAE和ACP活性。结果:与正常大鼠相比,CAG组大鼠一般状况欠佳,体质量明显减轻;大鼠胃黏膜萎缩、变薄,胃黏膜炎症程度积分和胃黏膜糜烂程度积分明显升高,而胃黏膜厚度和腺管总长度明显降低;空肠和肝也呈现出不同程度的病理学改变;大鼠上述脏器的糖原含量、SDH、ANAE、ACP和LDH活性多数显著降低;经黄芪建中汤治疗21d后,上述指标明显改善并明显优于维酶素组。结论:脾虚型CAG状态下,机体存在多脏器代谢紊乱,黄芪建中汤对之有良好的复健作用,其疗效显著优于维酶素。关键词黄芪建中汤;慢性萎缩性胃炎;脾虚;组织
3、代谢;大鼠EffectsofHuangqiJianzhongDecoctiononthedigestivesystemofratwithchronicatrophicgastritiswithsyndromeofspleendeficiency+LiuWanggenl,JiangShihon91,WangQil,WangXuepin91。WuJinglanz(1DepartmentofHistologyandEmbyology,HenanCollegeofTraditionalChineseMedicine,Zhengzhou45
4、0003,China;2DepartmentofHistologyandEmbryology,ZhengzhouUniversity,Zhengzhou450052,China)AbstractObjective.TostudythemechanismfortherapeuticeffectsofHuangqiJianzhongDecoction(HJD)onratmodelsofchronicatrophicgastritis(CAG)ofspleendeficiencytype.Methods:24Wistarratswere
5、randomlydividedintocontrol(C)group,CAGgroup,vitacoenzyme(V)groupandHJDgroup.SDH,LDH,ANAE,ACPandglyco-geninthestomachmncosa,junummucosa,liverandpancreasexocrinepartwereexaminedineachgrouprespective-lY.Results:ComparedwiththeCgroup。thebodyqualityinCAGgroupwasreducedmark
6、edlywithgeneralweakness.Thegastricmucosaebecameatrophyandthinnerwithobviouserosionandmoreinflammatorycells.Thestructuresofthejejunumandliveralsoweredestroyed.TheexpressionsofSDH,LDH,ANAE,ACPandglycogenwereweaker.Thereweresignificantdifferencesinallaboveparametersbetwe
7、entheCAGgroupandCgroup,andtheHJDgroupandVgroup.Conclusion:、7lmenchronicatrophicgastritis(CAG)withsyndromeofspleendeficiencyhappened,themetabolismisdisorderinseveralorgansasabove,whichcouldbeimprovedbyHJD.ThetherapeuticeffectsofHJDpredominatedovervitacoenzyme.KeywordsH
8、uangqiJianzhongDecoction;ch.ronicatrophicgastritis;syndromeofspleendeftciency;metabolism;rat现代中医研究认为慢性萎缩性胃炎(chronica—trophic
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