奥美拉唑、兰索拉唑和泮托拉唑预防重症脑卒中患者应激性溃疡的成本-效果分析

《奥美拉唑、兰索拉唑和泮托拉唑预防重症脑卒中患者应激性溃疡的成本-效果分析》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、临床合理用药2013年l1月第6卷第l1期中ChinJofChmc~RationalDrugUse。November2013，VoL6No．1lB·5··论著·奥美拉唑、兰索拉唑和泮托拉唑预防重症脑卒中患者应激性溃疡的成本一效果分析池宁娟，贾艳艳，赵先，鹿成韬，窦芳，文爱东【摘要】目的探讨3种质子泵抑制剂预防重症脑卒中患者应激性溃疡的成本一效果。方法310例重症脑卒中患者随机分为3组；A组105例，B组102例，c组103例。3组均予常规治疗，A组采用奥美拉唑预防，B组采用兰索拉唑预防，c组采用泮托拉唑预

2、防。比较各组的溃疡发生率、医院获得性肺炎发病率和总病死率，并进行成本一效果分析。结果3组溃疡发生率、预防应激性溃疡出血的有效率比较差异无统计学意义(P>0．05)。与B组和c组比较，A组医院获得性肺炎发病率较高，差异有统计学意义(P<0．05)；A组、c组病死率比较差异有统计学意义(P<0．05)，B组和c组比较差异无统计学意义(P>0．05)。3组成本—效果分别为23．5，23．1和11．4。结论泮托拉唑成本效果优于奥美拉唑和兰索拉唑。【关键词】奥美拉唑；兰索拉唑；泮托拉唑；重症脑卒中；应激性溃疡；成本

3、—效果分析【中图分类号】R573．1【文献标识码】A【文章编号】1674—3296(2013)11B一0005—02Cast-efectivenessanalysisofomeprazole．iansoprazoleandpantoprazoleinthepreventionofsIessulcerinpatientswithseverecerebralstrokeCHINing-juan，JIAYan-yan，ZHAOXian，eta1．HospitaloftheFourthMilitaryMedica

4、lUniversity，Xian，Shanxi710032，China【Abstract】ObjectiveToinvestigatethecost-efectivenessofcmeprazole，lansoprazoleandpantoprasoleinthepre—ventionofstressulcerinpatientswithseverecerebralstroke．Methods310casesofpatientswithSeverestrokewererandom-lydividedint

5、o3groups8．8groupA(105cases)，groupB(102cases)andgroupC(103cases)．The3groupsweregivenconventionaltherapy，thegroupAWaspreventedwithomeprazole，thegroupBWaspreventedwithlansoprazole，thegroupCWaspreventedtllpantoprazole．Theincidenceofulcer，theincidenceofh0spita

6、lacquiredpneumoniaandtheoverallmortalityratewereobservedandcomparedinthe3groups．Anddocostefectivenessanalysis．ResultsThereweresignificantdiferencesinaspectofincidenceofulcer，eficiencyrateofstressulcerbleedingpreventioninthe3groups(P<0．05)．Theincidenceofh0

7、spitalacquiredpneumoniaofgroupAWashigherthanthatofgroupBandgroupC，andthediferenceWasstatisticallysisni~-cant(P<0．05)．ThereWassignificantdiferenceinaspectofmortalityratebetweengroupAandgroupC(P<0．05)，butthereWasnosignificantbetweengroupBandgroupC(P>0．05)．T

8、hecost—efectii,enessofwasrespectively23．5，23．1and11．4．CondusionsThecost．efectivenessofpantoprazoleisbetterthanthatofomeprazoleandlansoprazole．【Keywords】Omeprazole；Lansoprazole；Pantoprazole；Severecerebralstroke；Stres