FeNO在不同妊娠周期孕妇及妊娠哮喘患者中的变化及意义.pdf

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5、I【摘要】目的观察呼出气一氧化氮(FeNO)在不同妊娠周期孕妇及妊娠哮喘患者中的变化，并探讨其在妊娠期哮喘患者中的诊治意义。方法收集健康妊娠女性46例(HP组)，健康非妊娠女性30例(HNP组)，哮喘非妊娠女性30例(ANP组)，哮喘妊娠期女性26例(AP组)。比较各组及HP组中不同妊娠周期孕妇的FeNO水平；分析AP组患者FeNO水平与第1秒用力呼气量占预计值的百分比(FEV％)、最大呼气流速峰值占预计值百分比(PEF％)的相关性。结果AP组及ANP组FEV％、PEF％均明显低于HNP组及HP组，FeNO水平均明显高于HNP组及HP

6、组，差异均有统计学意义(均P<005)；HNP组与HP组、AP组与ANP组FeNO水平、FEV、％及PEF％的差异均无统计学意义(均P>005o不同妊娠周期孕妇FeNO水平的差异均无统计学意义(均P>0．05oAP组患者FeNO水平与FEV％及PEF％均无明显相关性(r=0250、0．272，P>005)。结论妊娠及妊娠周期对FeNO水平无明显影响，AP患者FeNO水平明显升高，FeNO水平与肺功能无明显相关。【关键词】妊娠哮喘呼出气一氧化氮Variabilityoffractionalnitricoxideinwomenofdifferent

7、gestationperiodsandinasthmaticpregnantwomenWULiqin．LIZh一long，DAIWei，eta1．DepartmentofRespiratoryMedicine，theSecondAffiliatedHospitalofWenzhouMedicalUniversity，Wenzhou325027，China【Abstract】ObjectiveToassessthechangesoffractionalconcentrationofexhaledNO(FeNO)inwomenofdifferent

8、gestationperiodsandinasthmaticpregnantwomen．MethodsFortysixhealthypregnantwomen(HPgroup)and30non—preg-nanthealthywomen(HNPgroup)，and30non-pregnantasthmaticwomen(ANPgroup)and26pregnantasthmaticwomen(APgroup)wereenrolledinthestudyTheFeNOlevelsin4groupsandindifferentgestationpe

9、riodsofHPgroupwereevaluatedThecorrelationsOfFeNOlevelwithforcedexpiratoryvolumeinthefirstsecond(FEV1)／predictedFEVl(FEVl％)andpeakexpiratoryflow(PEF)／predictedPEF(PEF％)valuesinAPgroupwereanalyzedResultsThevaluesofFEV1％andPEF％weresignificant—lydecreasedandtheFeNOlevelswereelev

10、atedinAPandANPgroupsascomparedtoHNPandHPgroups(P<005)Nosig-nificantdifferencesofFeNOlevelsandFEV1％andPEF％valuesbetweenHNPandHPgroupsorbetweenANPandAPgroupswerefound(P>0o5)．TherewerenosignificantdifferencesinFeNOlevelsamongdifferentgestationperiodsinHPgroup(P>0．05)andnosignif

11、icantcorrelationsofFeNOlevelswithFEV1％andFeNOvaluesinAPgroupwererevealed(r=0．250，0272，re-spectively．P>0．05)ConclusionFeNOlevelmaynotbeinfluencedbypregnancystatusanddifferentgestationperiod；theFeNOlevelisincreasedinasthmaticpregnantwomen，however，itmaynotbecorrelatedwiththepul

12、monaryfunction【Keywords】PregnancyAsthmaFeNO支气管哮喘是妊娠妇女常见合并症I”。妊娠期哮喘检查可增加腹压，具