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时间:2017-12-08
《奥氮平与齐拉西酮对女性首发精神分裂症患者的疗效及体重泌乳素的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、隰穿瑗论筠簸髓2013年第26卷第24期Vo1.26,No.24,Dec2013JM。dTheor&Proc厂_13223奥氮平与齐拉西酮对女性首发精神分裂症患者的疗效及体重泌乳素的影响赵雅琴江苏省扬州五台山医院225004摘要目的:观察奥氮平与齐拉西酮治疗首发女性精神分裂症患者的疗效和对女性患者体重及泌乳素的影响。方法:将98例女性精神分裂症急性发作的患者随机分为奥氮平组(=48)、齐拉西酮组(一50),观察6周。在治疗前及治疗后第2、4、6周采用阳性和阴性症状量表评定疗效,并测量体重及进行实验室检查。结果:女性首发精神分裂症患者初次使用奥氮平、齐拉西酮治疗,总有
2、效率分别为83.3、78.00,两组有效率和无效率比较,差异无统计学意义(Y。=O.16,P>O.05);奥氮平组PANSS总分的改善优于齐拉西酮组(P<0.05);治疗后,齐拉西酮组体重及泌乳索未见明显变化(P>0.o5),奥氮平组体重及泌乳索显著增高(P3、奥氮平齐拉西酮中图分类号:R749.3文献标识码:A文章编号:1001—7585(2013)24—3223一O3OlanzapineandZiprasidoneSchizophreniaCurativeEffectandWeightofLactatingPatientsintheFirst-episodeFemaleSpiritZHAOYaqin.YangzhouWuTaiShanHospitalofJiangsuProvince225004ABSTRACTObjective:Toobservetheeffectsofolanzapineandziprasidone4、inthetreatmentoffirst-episodef~,.aleschizophreniapatientsandthefemalebodyweightandprolactir~Methods:98patientsoff~aleschizophreniaacuteonsetwel'e&videdintoolanzapinegroup(一48),ziprasidonegroup(,z=50),wereobservedfor6weeks.BeforetreatlTlelltandaftertreatmentin2,4,6weeksbypositiveandnega5、tivesymptotrksscaleassessmentofefficacy,andbodyweightmeasurementandlaboratoryexa]rI1ina—tion.Results:F~alefirst-episodescz0phreapatientswitholanzapine,zipmsidonetreatment,totaleffectiveratewas83.3,78%,tWOgroupsofe{f~ieneyeomp~on,nosignificantdifference(~z=0。16,P>0.05);ziprasidonegroupa6、ndolanzapine,groupwasbetterthanthatofPANSSscores(P0.05),n0weightandprolaetinincreasedsignificantly(P7、egroup(P
3、奥氮平齐拉西酮中图分类号:R749.3文献标识码:A文章编号:1001—7585(2013)24—3223一O3OlanzapineandZiprasidoneSchizophreniaCurativeEffectandWeightofLactatingPatientsintheFirst-episodeFemaleSpiritZHAOYaqin.YangzhouWuTaiShanHospitalofJiangsuProvince225004ABSTRACTObjective:Toobservetheeffectsofolanzapineandziprasidone
4、inthetreatmentoffirst-episodef~,.aleschizophreniapatientsandthefemalebodyweightandprolactir~Methods:98patientsoff~aleschizophreniaacuteonsetwel'e&videdintoolanzapinegroup(一48),ziprasidonegroup(,z=50),wereobservedfor6weeks.BeforetreatlTlelltandaftertreatmentin2,4,6weeksbypositiveandnega
5、tivesymptotrksscaleassessmentofefficacy,andbodyweightmeasurementandlaboratoryexa]rI1ina—tion.Results:F~alefirst-episodescz0phreapatientswitholanzapine,zipmsidonetreatment,totaleffectiveratewas83.3,78%,tWOgroupsofe{f~ieneyeomp~on,nosignificantdifference(~z=0。16,P>0.05);ziprasidonegroupa
6、ndolanzapine,groupwasbetterthanthatofPANSSscores(P0.05),n0weightandprolaetinincreasedsignificantly(P7、egroup(P
7、egroup(P
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