中药微调三号方联合香菇多糖对中晚期胃癌患者细胞免疫功能的影响

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1、1136E中医2010年8月第32卷第8期HebeiJ．r耻壁：：：中药微调三号方联合香菇多糖对中晚期胃癌患者细胞免疫功能的影响倪依群(南京中医药大学无锡附属医院肿瘤科，江苏无锡214001)【摘要】目的观察中药微调三号方联合香菇多糖对中晚期胃癌患者细胞免疫功能的影响。方法将47例中晚期胃癌患者随机分为2组，中药微调三号方联合香菇多糖组23例予中药微调三号方联合香菇多糖治疗，香菇多糖组24例予香菇多糖治疗。治疗2周后观察2组细胞免疫功能变化。结果中药微调三号方联合香菇多糖组治疗后自然杀伤(NK)细胞、CD3、CD4较本组治疗前升高(P<0．05)，香菇多糖组治疗后CD3、CD4

2、较本组治疗前降低(P<0．05)。中药微调三号方联合香菇多糖组治疗后NK低于香菇多糖组(P<0．05)，CD4高于香茹多糖组(P<0．05)。中药微调三号方联合香菇多糖组治疗后中医证候积分低于本组治疗前(P<0．05)，卡氏评分升高(P<0．05)；中药微调三号方联合香菇多糖组治疗后中医证候积分低于香菇多糖组(P<0．05)。结论中药微调三号方联合香菇多糖较单用香菇多糖能有效提高中晚期胃癌患者CD3、CD4细胞比例，提高NK细胞水平，从而提高患者细胞免疫功能。【关键词】胃肿瘤；免疫；中药疗法【中图分类号】R735．2；R289．6【文献标识码】A【文章编号】1002—2619(

3、2010)08—1136—03EfectofcornbinationoftraditionalChinesemedicineandJentinanoncellularimmunityinpatientswithme-diumandadvancedgastriccancerNIriqun．DepartmentofOncology，WuxiAffiliatedHospitalofNanjingUniversi—t，，ofTraditionalChineseMedicine，Jiangsu，Wuxi214001【Abstract】ObjectiveToinvestigatetheef

4、fectofcombinationoftraditionalChinesemedicineandlentinanoncellularimmunityinpatientswithmediumandadvancedgastriccancer．Methods47patientswithmediumandad—vancedgastriccancerwererandomlydividedintotwogroups．Patientsinlentinangroup(n：24)weretreatedbylentinan．23casesintraditionalChinesemedicineco

5、mbinedwithlentinangroupweretreatedbycombinationoftradi—tionalChinesemedicineandlentinan．Thechangesofcellularimmunitywereobservedaftertwoweeks．ResultsNKcell，CD3andCD4wasincreasedcomparedwiththosebeforetreatmentintraditionalChinesemedicinecombinedwithlentinangroup(JP<0．05)．CD3andCD4wasdecrease

6、dcomparedwiththosebeforetreatmentinlentinangroup(P<0．05)．NKwasdecreased，CD4wasincreasedcomparedwiththoseinlentinangroupaftertreatment(P<0．05)．SyndromesoftraditionalChinesemedicinescoreweredecreasedcomparedwiththosebeforetreatmentintraditiona1Chinesemedicinecombinedwithlentinangroup(P<0．05)．C

7、onelusi彻rhecombinationoftradi．tionalChinesemedicineandlentinancanincreaseratioofCD3andCIMinpatientswithmediumandadvancedgastriccancer，andraiseNKcellforimprovementofcellularimmunity．【Keywords】Stomachneoplasms；Immunization；TraditionalChinesemedicinet