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1、莫沙必利治疗114例胃食管反流病临床观察作者：赵忠岩1,李路平2,于倩2单位：1•吉林大学中日联谊医院急救医学科，吉林长春1300312吉林大学中日联谊医院约剂科，吉林长春130031【摘要】目的：评价莫沙必利治疗胃食管反流病(GERD)的作用及安全性。方法：采用随机对照临床研究的方法，将诊断为GERD的114例患者随机分为3组，奥美拉卩坐+莫沙必利组36例,奥美拉I野吗丁咻组38例，单纯奥美拉卩坐纽.40例,疗程为4周。结果:治疗2周时自觉症状的缓解率在3纽之间差异无统计学意义，但奥美拉哇+莫沙必利组治疗4周吋的症状缓解率明显优于甲纯奥美拉卩坐纽(P<
2、;0.05),血且在停药2周后症状的复发率也明显低于甲纯奥美拉II坐组(P<0.05),但与奥美啦I坐+吗丁I林组比较差界无统计学意义。治疗4周后监测食管下段24hpH值，结果表明，接受奥美拉II坐+莫沙必利治疗者pH值<4时间百分比(pH值<4时间％)和持续≥5min的反流次数比奥美拉卩坐+吗丁麻纽和单纯奥美拉H坐组明艶减少(P<0.05),但pH值<4的反流次数及下食管括约肌压力(LESP)在3纽间差异无统计学意义。结论：II服莫沙必利可以明显减少食管下段pH值<4时间％及长时间反流次数，并可有效的缓解GERD的
3、症状，且复发率较单纯应用奥美拉哇治疗明显降低。【关键词】莫沙必利;胃食管反流病;奥美拉I坐ClinicalobservationofMosaprideinthetreatmentofgastroesophagealrefluxdisease：Areportof114casesZHAOZhong-yan1,LILu-ping2,YUQian2(1.DepartmentofEmergency,China-JapanUnitedHospital,JilinUnivercity,Changchun130031,China;2.DepartmentofPharmacy
4、,China-JapanUnitedHospital,JilinUnivercity,Changchun130031,China)Abstract：ObjectiveToevaluatetheutilityandsafetyofMosaprideincuringgastroesophagealrefluxdisease(GERD).MethodAccordingtotheclinicalstudymethodofrandomcomparison,114patientsweredepartedintothreegroupsatrandom(36forOmepr
5、azoleandMosapride,38forOmeprazoleandDomperidoneand40foronlyOmeprazole).Thecourseoftreatmentlastedfourweeks.Resu11sAftertwoweeks*treating,therewasnosignificantdifferenceintheremissionrateoftherationalsymptomofthethree.Butafterfourweeks,theremissionrateofthegroupusingOmeprazoleandMos
6、apridewasobviouslyhigherthanthatusingOmeprazolesimplyandtherecurrencerateaftertwoweeks*discontinuationwasobviouslylowerthanthat,butithadnosignificantdifferencefromthegroupusingOmeprazoleandDomperidone.Monitoring24hpHafterfourweeks1therapy,theresultsshowedthatthetimepercentageofpH&l
7、l;4andtherefluxtimeslastingmorethan5minutesofthepatientsusingOmeprazoleandMosapridewereobviouslylowerthantheothertwogroups.ButtherewasnosignificantdifferenceoftherefluxtimesofpH<4andloweresophagealsphincterpressure(LESP)inthethreegroups.ConclusionMosaprideinadoseof30mg/dcausesas
8、ignificantdecreaseintheper
