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1、兰索拉卩坐和莫沙必利治疗老年胃食管反流病的临床观察［摘耍］H的:探讨兰索拉岬和莫沙必利联合用药对老年胃食管反流病的疗效。方法:将68例老年胃食管反流病患者随机分为两纟fl,治疗组采用兰索拉I唯和莫沙必利治疗,对照纟fl采用法莫替丁和莫沙必利,两组疗程为均6周,观察症状改善情况并复杳胃镜。结果:改善临床症状方面，治疗组显效19例,有效12例,无效3例,总有效率为91.18%;对照组显效16例,有效11例，无效7例，总有效率为79.41%0内镜检查显示治疗组治愈率为70.59%,总有效率为88.24%;对照纽治愈率为
2、58.88%,总有效率为76.47%。两组以上指标比较，均有非常显著性差异(P<0.01)o结论:兰索拉醴和莫沙必利联合用药是治疗老年人胃食管反流病的有效药物。［关键词］兰索拉哩;莫沙必利;法莫替丁；胃食管反流病［中图分类号］R57［文献标识码］A［文章编号］1673-7210(2009)08(b)-05602ClinicalobservationofLansoprazoleandMosaprideinthetreatmentofgastroesophagea1refluxdiseaseinelderlypati
3、ontsLUBaichun,WENChangsi(ZhangmutouHospitaiofDongguanCity,Dongguan523633,China)［Abstract］Objective:ToexploretheclinicalobservationofLansoprazoleandMosaprideinthetreatmentofGastroesophagealrefluxdiseaseinelderlypatients.Methods:68casesofGastroesophagealrefluxd
4、iseaseinelderlypatientswererandomlydividedintotwogroups,thetreatmentgroupwastreatedwithLansoprazoleandMosapride,thecontrolgroupwasgivenFamotidineandMosapride,thetwogroupsweretreatedfor6weeks,theefficacywascomparedandreexaminedgastroscopy.Results:Intheaspectso
5、fimprovingclinicalsymptoms,inthetreatmentgroup,19caseshadmarkedeffect,12caseswereeffective,3caseshadnoeffect,thetotaleffectiveratewas91.18%・Inthecontrolgroup16caseshadmarkedeffect,11caseswereeffective,7caseshadnoeffect,thetotaleffectiveratewas79.41%.Gastrosco
6、pyexaminationshowedthatinthetreatmentgroup,theoverallcureratewas70.59%,thetotaleffectiveratewas88・24%・Inthecontrolgroup,theoverallcureratewas58・88%,thetotaleffectiveratewas76.47%・Thereweresignificantdifferencesintheaboveindexesbetweenthetwogroups(P<0.01).Cone
7、lusion:LansoprazoleandMosaprideareeffectivedrugsusedforthetreatmentofgastroesophagealrefluxdiseaseinelderlypatients-［Keywords］Lansoprazole;Mosapride;Famotidino;Gastroesophagealrefluxdisease胃食管反流病(GERD)是指胃十二指肠内容物反流入食管，对黏膜食管刺激或造成损伤，从而引起临床症状，如烧心、反酸、胸痛、反食、恶心或食管炎症
8、，临床上可以表现为內镜阳性GERD,即内镜下具有食管黏膜破损、糜烂、溃疡等形成，即反流性食管炎(RE);也可以表现为内镜阴性GERD,即内镜下无糜烂性食管炎表现(NERD)CGERD可发生于所有年龄的人，以中老年人最常就医，男性食管炎的发病率要比女性高1倍,GERD的患病率在西方为7%,国内李定国［1］报道患病率在5.1%左右，随年龄的增加,GERD发病率也逐渐增加。老年
