埃索美拉唑联合莫沙比利治疗难治性GERD的临床研究.doc

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1、埃索美拉I坐联合莫沙比利治疗难治性GERD的临床研究作者：杨炎，刘华单位:上海市普陀区利群医院消化内科200072上海同济大学附属第十人民医院消化内科【摘要】目的探讨联合应用埃索美拉哇和莫沙比利治疗难治性胃食管反流病(「GERD)的临床疗效。方法⑸例rGERD患者随机分为三组:联合用药组5=51)、埃索美拉I坐组(】匸50例)和莫沙必利组(n=50),分别采用埃索美拉I坐+莫沙比利、埃索美拉II坐和莫沙比利，治疗4周及8周后复查内镜，并评价临床症状。结果联合用药纽•和埃索美拉卩坐纽.治疗前、治疗4周后和治疗8周后症状积分有明显下降趋势

2、(P<0.05)；渤了4周后和治疗8周后的联合用夯组的症状积分明显低于埃索美拉II坐纽(P&l〔;0.05)。联合用药组和埃索美拉I坐组在治疗4周后和治疗8周后与治疗前相比，内镜分级改善显著(P<0.05)；治疗4周后和治疗8周后联合用药纽的内镜分级改善明显高于埃索美拉II坐纽(P<0.05)；治疗4周及8周后，联合用药纽的治疗有效率明显高于埃索美拉II坐组。结论埃索美拉II坐联合莫沙比利治疗rGERD有很高的临床疗效。【关键词】胃食管反流病；埃索美拉II坐；莫沙比利StudyofEsomeprazoleCombin

3、edwithMosaprideinTreatmentofRefractoryGiistroesophagealRefluxDiseaseYangYan,LiuHuaDepartmentofGastroenterology,PutuoLiqunHospitaljiaotongUniversity,200080,China【Abstract]ObjectiveToevaluatetheeffectofesomeprazolecombinedwithmosaprideonrefractorygastroesophagealrefluxdis

4、ease(rGERD).MethodsAtotalof151rGERDpatientswererandomlydividedinto3groups：Combinationgroup(n=51),Esomeprazolegroup(n=50)andMosapridegroup(n=50),treatedwithesomeprazoleplusmosapride,esomeprazoleandmosapride,respective!y.Theclinicaloutcomesandendoscopywereobservedandanaly

5、zedafter4and8weeksoftreatment.ResultsThesymptomscoreofcombinationgroupandesomeprazolegrouphavethedecreasedtrendinbefore,after4wksand8wksoftreatment(P<0.05)・Thesymptomscoreofcombinationgroupafter4and8weeksoftreatmentaresignificantlylowerthanthatofesomeprazolegroup(P&l

6、t;0.05)・Thereexistthesignificantendoscopygradeimprovementofcombinationgroupandesomeprazolegroupafter4and8weeksoftreatment(P<0.05)・Theendoscopygradeimprovementofcombinationgroupisstrongerthanthatofesomeprazolegroupafter4and8weeksoftreatment(P<0・05)・After4and8weekso

7、ftreatment,theeffectiveratesofcombinationgrouparehigherthanesomeprazolegroup(P<0.05)・ConclusionEsomeprazolecombinedwithmosapridemaybehighlyeffectiveinthetreatmentofrGERD・【Keywords]Gastroesophagealrefluxdisease;Esomeprazole;Mosapride胃食管反流病(gastroesophagealretluxdiseas

8、e,GERD)是胃和(或)十二指肠内容物反流人食管引起烧心、反酸症状或组织损害。质子泵抑制剂(protonpumpinhibitors,PPI)能有效抑制胃酸,目前国内外一般釆用以PPI作为基础治疗用药,第一代PPI如奥