[精品][经典]环磷腺苷葡胺与低分子肝素治疗肺源性心脏病急性加重期疗效观察.doc

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1、［经典］环磷腺昔葡胺与低分子肝素治疗肺源性心脏病急性加重期疗效观察环磷腺昔葡胺与低分子肝素治疗肺源性心脏病急性加重期疗效观察【摘要】冃的探讨环磷腺昔葡胺和低分子肝素治疗肺源性心脏病急性加重期治疗效果。方法将67例肺源性心脏病急性加重期患者随机分成2组，对照组（33例）给予吸氧、抗生素、平喘、扩血管及利尿等常规治疗；治疗组（34例）在常规治疗的基础上加用环磷腺昔葡胺120mg加入5%葡萄糖溶液250ml静脉滴注，1次/d；低分子肝素2500U,皮下注射，12h/次。疗程共7d。治疗前后进行心功能分级

2、评估、血气分析和心脏超声检查。结果治疗组患者心功能、血气分析和各项心脏指数较对照组改善更为显著（P〈0・01）o结论环磷腺苛葡胺和低分子肝素对急性加重期肺源性心脏病患者疗效显著。令【关键词】肺源性心脏病；急性加重期；环磷腺昔葡胺；低分子肝素ClinicaleffectofmeglumineadenosioncyclophosphateandlowmolecularweightheparinonpatientswithcorpulmonaleatacutedeteriorationstageWANG

3、Zhe-mou,ZhangDe-mei,YuYan.DepartmentofMedicineofLaixiMaternityandChildCareCentre,Laixi,,ShandongProvince266600,China[Abstract]ObjectiveTosurveythetherapeuticeffectonpatientswithcorpulmonaleatacutedeteriorationstagebymeglumineadenosioncyclophosphateand

4、lowmolecularweightheparin.Methods67caseswithcorpulmonaleatacutedeteriorationstagewererandomlydividedintotwogroups・Patientsinthecontrolgroup(33cases)weretreatedwithroutinetreatmentincludingoxygenuptake,antibiotics,antiasthmatics,vasodilators,diuretics,

5、etc.Inadditiontotheroutinetreatment,patientsinthetreatmentgroup(34cases)weretreatedwith120mgofmeglumineadenosioncyclophosphateinjectionthroughintravenousdriponceadayand2500Uoflowmolecularweightheparinthroughsubcutaneousinjectiontwiceadayfor7days・Weobs

6、ervedthechangesofcardiacfunction,pulmonaryarterypressure(PAP),leftventricularejectionfraction(LVEF)andanalysisofthegasesinbloodbeforeandafterthetreatment.ResultsPatientsinthetreatmentgrouphadmoresignificantimprovementsinheartfunctionandthegasesinblood

7、thanthoseinthecontrolgroup(P<0.01).ConclusionMeglumineadenosioncyclophosphateandlowmolecularweightheparinaresignificantlyeffectivetotreatcorpulmonaleatacutedeteriorationstage・❷[Keywords】Corpulmonale;Acutedeteriorationstage;Meglumineadenosioncyclophosp

8、hate;Lowmolecularweightheparin肺源性心脏病急性加重期患者由于心肺功能差、胃肠道瘀血，往往存在多系统、多器官功能受累，临床上治疗较为困难，病死率高。应用环磷腺苛葡胺和低分子肝素治疗肺源性心脏病急性加重期患者,取得了满意疗效，现报告如下。❷1资料和方法❷1.1一般资料本组67例患者均为2003年4月至2007年10月住院病例，全部病例诊断均符合中华医学会呼吸病学分会制订的肺源性心脏病急性加重期诊断标准^[l],并排除了其他心脏疾患所致的