cme联合术中动脉灌注及腹腔内间质缓释剂化疗的研究

《cme联合术中动脉灌注及腹腔内间质缓释剂化疗的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、1460中国肿瘤临床2013年第40卷第23期ChinJClinOncol2013，Vo1．40，No．23WWW．cjco．cnCME联合术中动脉灌注及腹腔内间质缓释剂化疗的研究师鲁静刘文志张旭高海德柳仲林崔佑刚冯宁摘要目的：探讨CME联合术中动脉灌注及腹腔内间质缓释剂化疗的安全性及疗效。方法：选取行CME联合术中动脉灌注并腹腔内间质缓释剂化疗的结肠癌患者1044~4为试验组，98例行结肠癌根治术患者为对照组。检测患者术前、术后血常规、肝’肾功能，记录术后不良反应、并发症发生率。检测试验组癌组织、癌旁组织、术后引流液以及外周血5

2、-FU浓度。随访3年，记录两组患者局部复发率、肝脏转移率、无疾病进展生存率及总生存率。结果：两组术前、术后血常规、肝肾功能，术后不良反应、并发症发生率无显著性差异(P>O．05)。试验组癌组织中5一Fu浓度明显高于癌旁组织。试验组患者术后第3天腹腔内引流液5-FU浓度显著升高，同时外周血5一Fu浓度达到峰值。试验组淋巴结转移率、肝脏转移率、无疾病进展生存率及3年总生存率均明显优于对照组，差异具有统计学意义(P<0．05)。结论：试验组患者的治疗安全有效，明显提高无疾病进展生存率和3年总生存率，且能显著降低结肠癌的淋巴结转移率和肝脏

3、转移率。关键词结肠肿瘤完整结肠系膜切除术动脉灌注化疗间质缓释化疗doi：10．3969／j．issn．1000—8179．20130277Completemesocolicexcisioncombinedwitharterialinfusionandintra--peritonealinterstitialsustained．．releasechemotherapiesforcolorectalcancerLujingSHI，WenzhiLIU，XuZHANG，HaideGAO，ZhonglinLIU，YougangCUI，Nin

4、gFENGCorrespondenceto：WenzhiLIU；E—mail：LWZ65888@yahoo．corn．cnDepartmentofGastrointestinalSurgery,ZhongshanHospitalofDalianUniversity,Dalian116001，China．AbstractObjective：Toinvestigatethesafetyandefectofcompletemesocolieexcision(CME)combinedwitharterialinfusionchemothe

5、rapy(AIC)andintra—peritonealinterstitialsustained—releasechemotherapy(IPISRC)．Methods：Atotalof104patientswereclassifiedundertheexperimentalgroupandunderwentCMEcombinedwithAICandIPISRC．Theother98patientswereclassifiedun—derthecontrolgroupandonlyreceivedradicalsurgery．P

6、re—andpost—operativebloodroutineexaminations，aswellasliverandkidneyfunctiontests，wereconductedforbothgroups．Post—operativeadversereactionsandincidenceofcomplicationswererecorded．Cancerandpara—neoplastictissuesweresampledinexperimentalgroup．Thepost-surgery5一fluorouraci

7、l(5-FU)concentrationinthedrainagefluidaswellasthoseintheperipheralblood，weredetermined．Three—yearfollow-upswereconducted，duringwhichthelocalrecur—rencerate，livermetastasis，progression·freesurvivalrate，andtotalsurvivalratewererecorded．Results：Nosignificantdiferenceswer

8、efoundinthewhitebloodcellcount，hemoglobincount，liverandrenalfunctionsofthepatientsbeforeandafterthesurgery,andrateofadverser