口服牛磺酸颗粒佐治小儿支气管哮喘急性发作的临床疗效-论文.pdf

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1、·74·PjICCPVDDecember2014．Vo1．22No．12·哮喘防治专栏·口服牛磺酸颗粒佐治小儿支气管哮喘急性发作的临床疗效徐文忠，艾桂莲，高美秀，洪潆，邵桂华【摘要】目的观察口服牛磺酸颗粒佐治小儿支气管哮喘急性发作的临床疗效。方法选择2011年2月014年2月永丰县人民医院收治的支气管哮喘急性发作患儿160例，随机分为观察组和对照组，各80例。两组患儿均予常规治疗，观察组患儿在常规治疗基础上口服牛磺酸颗粒，比较两组患儿临床疗效、临床症状(包括咳喘和肺部哮鸣音)消失时间及住院时间。结果观察组惠儿总有效

2、率为95．0％，高于对照组的76．2％(P<0．05)；观察组惠儿咳喘消失时间、肺部哮鸣音消失时间及住院时间均短于对照组(P<0．05)；两组惠儿均未出现明显不良反应。结论口服牛磺酸颗粒佐治小儿支气管哮喘急性发作疗效确切，能有效改善患儿临床症状，缩短患儿住院时问，且安全性良好。【关键词】哮喘；儿童；牛磺酸颗粒；治疗结果【中图分类号】R562．25【文献标识码】Bdot：10．3969／j．issn．1008—5971．2014．12．032ClinicalEfectofOralTaurineGranulesinth

3、eAdjuvantTreatmentofAcuteExacerbationofBronchialAsthmainChil-drenXUWen～zhong，AIGut—lian，GAOMei—xiu，eta1．PeoplesHospitalofYongrengCounty，Ji(zn331500，China【Abstract】ObjectiveToobservetheclinicaleffectoforaltaurinegranulesintheadjuvanttreatmentofacuteexacer-barto

4、nofbronchia1asthmainchildren．MethodsAIotalofl60childrenwithacuteexacerbationofbronchialasthmawerese—lectedinthePeopleSHospitalofYongfengCountyfromFebruary2011toFebruary2014，andtheywererandomlydividedintoobservationgroupandcontrolgroup，eachof80cases．Bothgroupsg

5、ivenconventionaltreatment，andobservationgroupgivenex—traoraltaurinegranules．Clinicaleffect，clinicalsymptomsdisappearedtimeandhospitalizationtimebetweenthetwogroupswerecompared．ResultsThetotaleffectiverateofobservationgroupwas95．0％．washigherthanthatofcontrolgro

6、upof762％(P<0．05)．Thedisappearedtimeofcoughandasthma，lungwheezing，andlmspitalizationtimeofobservationgroupwereshorterthanthoseofcontrolgroup(P<0．05)．Nooileofthetwogroupsoccurredobviousadversereactionsduringtreatment．ConclusionOraltaurinegranuleshascertainclinic

7、aleffectintheadjuvanttreatmentofacuteexacerbationofbronchialasthmainchildren，caneffectivelyrelieftheclinicalsymptoms，shortenthehospitalizationtime，andiswithhighsafety．【Keywords】Asthma；Child；TaurineGranules；Treatmentomcome小儿支气管哮喘多发于5岁以下儿童，由多种细胞特别是院收治的支气管哮喘急性发作患

8、儿160例，均符合2008年中肥大细胞和嗜酸粒细胞参与气道慢性炎症所致，如早期未能及华医学会儿科学组呼吸分会制定的相关诊断标准，且未经正规时控制可引起气道重塑，肺功能受损加重，症状难以控制，预治疗，排除支气管异物、支气管淋巴结结核、先天性上下气道后不佳⋯。糖皮质激素联合B受体激动剂吸人对小儿支气管畸形、心源性哮喘等疾病。将患儿随机分为观察组和对照组，哮喘急性