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1、2010年2月中成药February2010第32卷第2期ChineseTraditionalPatentMedicineVo.l32No.2痰热清佐治支气管哮喘急性发作的疗效分析及机制探讨*林剑勇,蒙兰青,罗维贵,李兴艳(右江民族医学院附属医院呼吸内科,广西百色533000)关键词:痰热清注射液;内皮素;肿瘤坏死因子;支气管哮喘急性发作摘要:目的:观察痰热清(黄芩、熊胆粉、山羊角、金银花、连翘)佐治支气管哮喘急性发作的疗效。方法:107例支气管哮喘急性发作患者随机分为痰热清治疗组(常规
2、治疗加痰热清,n=52),对照组(常规治疗,n=55),分析2组疗效,测定治疗前后血清内皮素(ET)和肿瘤坏死因子(TNF)含量。结果:治疗组疗效明显优于对照组,治疗后治疗组血清ET和TNF的含量比对照组低(P<0.01)。结论:抑制ET和TNF的分泌,干预炎症反应,可能是痰热清治疗支气管哮喘急性发作的机制之一。中图分类号:R287文献标识码:A文章编号:10011528(2010)02018403ClinicalobservationofTanreqingI
3、njectionintreatmentofpatientswithacuteasthmaLINJianyong,MENGLanqing,LUOWeigu,iLIXingyan(DeptofRespiratoryMedicine,HospitalAffiliatedtoYoujiangMedicalCollegeforNationalities,Baise533000,China)KEYWORDS:TanreqingInjection;ET;TNF;acuteasthmaABSTRAC
4、T:AIM:ToobserveclinicalefficacyofTanreqingInjection(RadixScutellariae,Beargallpowder,Ramshorn,FlosloniceraejaponicaeandFructusforsythiae)intreatmentofpatientswithacuteattackofbronchialasthma.METHODS:Onehundredandsevenpatientswithanacuteasthmawererandom
5、lyassignedintotwogroups:atreatmentgroup(n=52,treatedbyTanreqingInjectionfor10dinadditiontotheroutinemedications)andacontrolgroup(n=55,treatedbyroutinemedications).TheserumlevelsofETandTNFweredeterminedbyradioimmunoassaybeforeandaftertreatmen,trespecti
6、vely.RESULTS:Beforetreatmen,ttherewerenosignificantdifferencesinthecontentofserumETandTNFbetweenthetreatmentgroupandthecontrolgroup.However,after10doftreatmen,tthelevelsofETandTNFinthetreatmentgroupweresignificantlylowerthanthoseofthecontrolgroup(
7、P<0.01),andclinicalefficacyofthetreatmentgroupwassuperiortothecontrolgroup.CONCLUSION:InhibitionofETandTNFsecretionandinterventioninflammatoryresponsemightbeoneofmechanismsofTanreqingInjectionintreatmentforacuteasthma.支气管哮喘(简称哮喘)是由嗜酸性粒细胞、肥中药因具有扶正固
8、本、多作用靶点的特点而受到人大细胞、T淋巴细胞、中性粒细胞等多种炎性细胞及们青睐。痰热清注射液由黄芩、熊胆粉、山羊角、金银细胞因子参与的气道慢性炎性疾病。哮喘是一种炎花、连翘等科学组方,严格按照中药指纹图谱生产而症性疾病的认识,对诊断和防治都有指导性意义。成。痰热清已广泛应用于肺部感染性疾病的治疗,而随着对哮喘研究的不断深入,哮喘的药物治疗有了痰热清治疗支气管哮喘近年来也陆续有报道,但对其很大的突破,其重点已从单纯缓解气道平滑肌痉挛,疗效的具体分析和作用
