基于数据挖掘的国家级名老中医治疗肿瘤用药规律研究-论文.pdf

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1、·50·ChinesedournalofInformationonTCMJun．2015VoI．22No．6基于数据挖掘的国家级名老中医治疗肿瘤用药规律研究宋京关，吴嘉瑞’，姜迪1．北京中医药大学，北京100102；2．北京市卫生局临床药学研究所，北京100035摘要：目的探讨国家级名老中医治疗肿瘤的用药规律。方法收集国家级名老中医治疗肿瘤处方，采用关联规则apriori算法和复杂系统熵聚类方法，确定处方中各单味药物频次、药物组合频次、药物之间的关联规则和核心组合等。结果高频药物包括黄芪、半夏、茯苓、白花蛇舌草、生地黄等；高频药

2、物组合包括“白术，茯苓”“陈皮，茯苓”“白术，党参”“茯苓，党参”等：置信度为1的关联规则包括“三棱一莪术”“牡丹皮，桃仁一赤芍”等：新处方包括“莪术，三棱，穿山甲，夏枯草，续断”“重楼，沙参，皂角刺，海藻，昆布”等。结论名老中医治疗肿瘤处方多用补脾益气、清热解毒、活血化瘀之品，符合中医标本兼治之用药原则。关键词：肿瘤：名医经验；用药分析；关联规则：聚类算法DOI：10．3969／j．issn．1005—5304．2015．06．015中图分类号：R2-05：R273文献标识码：A文章编号：1005—5304(2015)06—0

3、050—04AnalysisontheMedicationRulesofNationalTCMMastersfortheTreatmentofPhymatosisBasedonDataMiningSONGJing-mei，wuJia-rui，JIANGDi．BeijingUniversityofChineseMedicine,Beijing100102．China~2．InstituteofClinicalPharmacyofBeijingMunicipalHealthBureau．Beijing100035，China)Abs

4、tract：0biectiveToexplorethemedicationrulesofnationalTCMmasters’treatmentforphymatosis．MethodsTheprescriptionsforphymatosisofnationalTCMmasterswerecollectedtobuildadatabase．Themethodsofassociationruleswithapriorialgorithmandcomplexsystementropyclusterwereusedtoachieve

5、frequencyofindividualherbs，frequencyofmedicinecombinations，associationrulesofherbsandcoremedicinecombinations．ResultsIntheprescriptionsforphymatosis，ChinesemedicinalherbswiththehighestfrequencywereAstragaliRadix，PinelliaeRhizoma，Poria，HerbaOldenlandiae，RehmanniaeRadi

6、xExsiccata，andSOon．MedicinecombinationswiththehighestfrequencywereAtractylodisMacrocephalaeRhizoma—Poria，CitriReticulataePericarpium—Poria，AtractylodisMacrocephalaeRhizoma—CodonopsisRadix，andPoria—CodonopsisRadix．Themedicineassociationrulesofconfidencecoeficient1were

7、SparganiiRhizoma--*CurcumaeRhizoma，andMoutanCortex，PersicaeSemen--~PaeoniaeRadixRubra．Thenewprescriptionscompositedby“CurcumaeRhizoma，SparganiiRhizoma，ManisSquama，PrunellaSpica，DipsacusAsperoides”，or“ParidisRhizoma，AdenophoraeRadix，GleditsiaeSpina，Sargassum，Laminaria

8、eThallus”．ConclusionsChinesemedicinalherbsusedintheprescriptiOnsofnationalTCMmastersforthetreatmentofphymatosiswereoftenwiththeacti