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1、中国肿瘤临床与康复 2000年第7卷 第6期51·论著·经皮门静脉穿刺注射IL2联合TACE治疗肝癌门脉癌栓疗效观察顾明,王迎春,王纯斌,卞杰盐城市第三人民医院肿瘤科 江苏(盐城224001)[摘要]目的 探讨TACE与经皮肝穿门静脉注射白介素2联合治疗肝癌并门脉癌栓患者的疗效。方法22例单纯TACE(对照组),16例TACE联合经皮门静脉注射IL2治疗(治疗组)治疗肝癌,有效率和生存期进行对比分析。结果 肝癌瘤体变化,两组无明显差异;门脉癌栓,对照组消失率4.5%,缩小36.4%,总有效率40.9%,治疗组分别为12.5%、50%、62.5%;生存率,对照组0.5、1.0、1.5、2
2、.0年生存率分别为45.5%、27.3%、0和0,治疗组分别为56.3%、31.5%、12.5%、6.3%,中位生存期分别为5.7M和8.7M,1.5、2.0年生存率对比(P<0.05)。结论TACE联合经皮门静脉注射IL2可提高肝癌并门脉癌栓的疗效,延长生存期。[关键词] 肝癌;门脉癌栓;白介素;经导管动脉化学栓塞术[中图分类号]R730.50R735.7[文献标识码]B[文章编号]1005-8664(2000)06-51-02Observaiononeffectsoftranscanteterarterialembolizationandpercutaneousinjectiono
3、fIL2intoportalveinonhepaticcarcinomaGUMing,WANGYing2chun,WANGChun2bin,etal.DepartmentofOncology,YanchengThirdHospital[Abstract]ObjectiveToevaluatetheeffectofTACEcompaniedbypercutaneousinjectionofIL2intoportalveinonpa2tientswithhepaticcarcinomacomplicatedwithcarcinomaticembolusinportalvein.Method
4、sTACEwasperformedin22casesascontrolgroupofTACEcombinedwithportalveininjectionofIL2werecarriedoutin16casesasstudygroup.Theeffective2nessandsurvivalratewereanalysed.ResultsThechangeoftumorsizewerenotsignificant,butcarcinomaemboluslessenedin36.4%,resolvedin4.5%incotralgroup,asaresult,thetotaleffect
5、iveratewas40.9%.Itlessenedin62.5%,resolvedin12.5%respectvelyinthestudygroup.Survivalrateof0.5year,1,1.5,5and2were45.5%,27.3%,0%,0%,respectivelyinthecontrolgroupbutinthestudygroupwere56.3%,37.5%,12.5%,6.3%,respectively.Themedianofsurvivaltermwere5.7monthsincontrolgroup,but8.7monthsinthestudygroup
6、(P<0.05).ConclusionsTACEcombinedwithinjectionofIL2in2toportalveinisefficientforhepaticcarcinomawithportalcarcinomaticembolustoincreaseeffectiverateandprolongsurvivalterm.[Keywords]hepaticcarcinoma;portalveincarcinomaembolus;IL2;TACE[1] 肝癌合并门静脉癌栓发生率可高达73.9%,它插管,将导管送至肝总动脉、肝固有动脉或肝左右动脉不仅是肝癌肝内转移、也是门
7、静脉系继发恶性肿瘤的后进行灌注化疗及栓塞治疗,化疗药物:ADM(或主要途径。临床预后差,亦无令人满意的治疗方法。THP)40~50mg、MMC12~14mg、DDP80~100mg、本文采用经导管肝癌供血动脉化学栓塞术(Tran25FU1000~1250mg,采用三联用药。栓塞物:碘油7~scatheterarterialchemoembolization,TACE)和经皮经30ml,40天左右重复治疗一次,二次为一疗程。肝门静脉穿刺注射介素2