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1、第28卷第2期中华中医药学刊Vo.l28No.22010年2月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEFeb.2010苓甘五味姜辛汤加味对变应性鼻炎豚鼠IL-4和IFN-C含量的影响方素清(辽宁中医药大学附属第一医院,辽宁沈阳110032)摘要:目的:观察苓甘五味姜辛汤加味对变应性鼻炎(AR)豚鼠血浆IL-4含量和IFN-C含量影响,揭示苓甘五味姜辛汤加味治疗AR的部分现代生物学基础。方法:将40只Wistar雄性豚鼠按体重随机分成生理盐水对照组、变应性鼻炎模型对照组、
2、苓甘五味姜辛汤加味治疗组、息斯敏治疗组,每组10只。采用卵蛋白全身致敏与局部攻击方法制作AR豚鼠模型,观察苓甘五味姜辛汤加味治疗后血浆IL-4含量和IFN-C含量的变化,结果进行统计学分析。结果:模型组血浆IL-4含量和IFN-C含量明显升高,苓甘五味姜辛汤加味治疗组血浆IL-4含量和IFN-C含量明显降低。苓甘五味姜辛汤加味治疗组优于息斯敏治疗组。结论:苓甘五味姜辛汤加味治疗AR的作用机制之一可能是通过降低IL-4含量和提高IFN-C含量,从而减轻鼻黏膜变应性炎症,减轻AR的症状或减缓AR的发作,以达到治疗AR的
3、目的。关键词:苓甘五味姜辛汤加味;变应性鼻炎;细胞因子;IL-4、IFN-C中图分类号:R285.5文献标识码:A文章编号:1673-7717(2010)02-0444-03LingGanJiangXinDecoctionAllergicRhinitisinGuineaPigsontheIL-4andIFN-CLevelsFANGSu-qing(TheFirstAffiliatedHospitalofLiaoningUniversityofTCM,Shenyang110032,Liaoning,China)Abst
4、rac:tObjective:ToobservetheflavorsLingGanJiangXinDecoctiononallergicrhinitis(AR)guinea-pigplas-maIL-4contentandtheimpactofIFN-Clevels,revealingflavorsLingGanJiangXinDecoctionARpartofthebasisofmodernbiology.Methods:40wistarmaleguineapigswererandomlydividedintos
5、alinecontrolgroup,allergicrhinitismodelcontrolgroup,withmixed-LingGanJiangXinDecoctiongroup,Astemizoletreatmentgroup,10ineachgroup.SensitizedusingovalbuminsystemicandlocalproductionofARinguineapigmodelofattackmethodstoobservetheLingGanJiangXinDecoctioninplasma
6、IL-4contentandcontentchangesofIFN-Cresultswerestatisticallyanalyzed.Re-sults:TheplasmaIL-4levelsandIFN-Cweresignificantlyincreased,withmixedLingGanJiangXinDecoctiontrea-tmentgroup,plasmaIL-4levelsandIFN-Cweresignificantlyreduced.LingGanJiangXinflavorsDecoction
7、treatedgroupwassuperiorAstemizoletreatmentgroup.Conclusion:LingGanJiangXinDecoctionflavorstheroleofARmaybeoneofthemechanismsbyreducingIL-4levelsandincreasedIFN-Clevels,thusalleviatingthenasalmucosaofaller-gicinflammation,reducingARsymptomsorslowtheonsetofAR,in
8、ordertoachievethepurposeoftreatmentofAR.Keywords:LingGanJiangXinDecoction;allergicrhinitis;cellfactor;IL-4,IFN-C变应性鼻炎(AllergicRhinitis,AR)是由IgE介导的I脾、肾三脏的虚损,自拟苓甘五味姜辛汤加味对变应性鼻炎型超敏反应性疾
