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1、#334#中国老年学杂志2009年2月第29卷不同剂量阿司匹林抗血小板治疗老年冠心病的临床研究1孙彤唐海沁黄晓晖李结华刘先进杨维维(安徽医科大学第一附属医院老年心血管内科,安徽合肥230022)1摘要2目的研究老年冠心病患者不同时间间隔,服用不同剂量阿司匹林抗血小板的疗效和安全性。方法120例老年冠心病患者随机分成6组:阿司匹林75mg,每天一次(75mg/qd)组,阿司匹林100mg,隔天一次(100mg/qod)组,阿司匹林100mg,每天一次(100mg/qd)组,阿司匹林150mg,隔天一次(150mg/qod)组,阿司匹林150mg,
2、每天一次(150mg/qd)组,对照组。服药7d后,观察服药前后各组血小板聚集率、白细胞、血小板数目、止凝血指标的变化。结果与对照组比较,各组对血小板聚集有显著的抑制作用。组间比较,阿司匹林75mg/qd和阿司匹林100mg/qod;阿司匹林100mg/qd和阿司匹林150mg/doq比较,服药前后血小板聚集率的差值无显著差异(P>0105)。各组服药前、7d后白细胞、血小板数目、止凝血指标无显著变化(P>0105)。阿司匹林75mg/qd组与阿司匹林150mg/qd组比较,服药7d后血小板聚集率差异显著(P<0105)。结论老年冠心病患者服用
3、阿司匹林75mg/qd和阿司匹林100mg/qod能起到同样抗血小板作用;同样阿司匹林100mg/qd和阿司匹林150mg/qod抗血小板的疗效相同,且较安全。1关键词2阿司匹林;血小板;老年人;冠心病1中图分类号2R541141文献标识码2A1文章编号2100529202(2009)0320334203Effectofanti2platelettherapywithdifferentdosesofaspirininelderlycoronaryheartdiseasepatientsSUNTong,TANGHai2Qin,HUANGXiao2
4、Hu,ietal1DepartmentofCardiacHealth,theFirstAffiliatedHospitalofAnhuiMedicalUniversity,Hefei230022,Anhu,iChina=Abstract>ObjectiveTostudytheeffectandsafetyofdifferentdosesofaspirinatdifferenttimeintervalsinelderlycoronaryheartdisease(CHD)patients1Methods120elderlyCHDpatientswe
5、rerandomlydividedintoaspirin75mgdaily,aspirin100mgeveryanotherday,aspirin100mgdaily,aspirin150mgeveryanotherday,aspirin150mgdailyandplacebogroups1Thetreatmentwascontinuedforsev2endays1Beforeandafterthetreatment,theplateletaggregationrate,thenumberofwhitebloodcell(WBC)andplat
6、eletandcoagulationweretested1ResultsTheplateletaggregationratewassignificantlyinhibitedinaspirintreatmentgroupscomparingwiththatinplacebogroup(P<0105),anditwasnotdifferentbetweenaspirin75mgdailygroupand100mgeveryanotherdaygroup,betweenaspirin100mgdailygroupand150mgdailygroup
7、(P>0105)1ThenumberofWBC,plateletandcoagulationaftertreated7dayswasnotdifferentwithpro2treated1ConclusionsAspirinboth75mgdailyand100mgeveryanotherdayhavetheequaleffectofanti2plateletaggregationdefinitelyandsafelyinelderlyCHDpatients1Sodoaspirin100mgdailyand150mgeveryanotherda
8、ytreatment1=Keywords>Aspirin;Platelets;Elderlypatients;Coronaryheartdisease
