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1、第31卷第11期中华中医对梦刊VoL31No.ll201311月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINENov.2013年冠心合剂减少大鼠心肌梗死边缘区凋亡及对-FasFasLCasase8Casase-、3蛋白表达的影响、、pp陈铁龙,祝光礼,赫小龙,齐国安杭州市中医院浙江中医药大学附属广兴医院心内科,浙江杭州310007)(心:摘要:目的:观察不同剂量冠合剂对大鼠急性心肌梗死边缘区细胞凋亡及探讨可能作用途径。方法取雄性SD大鼠80只,随机分为模型组、冠心合剂高剂量组、中
2、剂量组、低剂量组和对照组。连续灌胃7d后,结扎冠状动脉左前降支造成急性心肌梗死模型,对照组不结扎冠状动脉左前降支,手术后4.5h留取心脏标本。检测Fa-s-比较冠心合剂组可明sFa8LCasase8Casae3:与模型组梗死边缘区细胞凋亡以及,,p,p蛋白表达量。结果,-显减少心肌细胞凋亡能减少FasFasLCasase-8Casase3的蛋白表达量。其中冠心合剂大剂量组减少心,并,,p,p心合剂能够保护缺血诱导的心肌细胞凋亡制FaCa-8sFasLsase肌细胞凋亡效果最明显。结论:冠,其作用机,,p,Cse-asa
3、3蛋白表达水平有关p。Fa--关键词:冠心合剂急性心肌梗塞凋亡sFasLCasase8Casase3;;;;;p;pR332A文章编号1673-77--17201311245303中图分类号:::文献标志码()xIiGuanittithAtMilftinHeReducinoosisinRaswcueocardanarconandjgAppynFasFasL--ExEffectsoCasasei8Casase3ressons,,p,pp’CHENTielong,ZHUGuangli,HEXiaolong,QIGuoanH
4、anzhouHoslildZitalofTCMGuanxinHositaAfiatetoheian(gp,ggpjgChMlUniHhou310007ZhiinineseedicaiverstanzeanChay,g,jg,)nve?Abstract:Obective:ToistiatetheefectsofdifferentdosaesofGuanxinHeionaotosisinratswithacutemjggpyjpocard.lrlddedmodelialinfarctionanditsossiblemech
5、anismMethods80maeSDatswererandomiviinto5rousp:ygp:--?roh?roushamuhdoseduanxrtmentdkdirou28/(kgGinHeietreamediumoserou14/gp,gp,ggp[g)],[(jpgpggnxnrereamen-*GuaiHeilowsrkdGrertment.Aferbenadmnsredtttdoeoup7/uanxinHeiteatiiite)jp],g[g(g)]jpgcorresondnmedcneordasall
6、rousexcetshamrouunderwencoronarlaonoflefaneodesceigiif7ytitittrirndingp,gppgpygm?branchtoestablishacuteyocardialinfarctionmodelsandshamrouonlreceivedthoracotomwithoutcoronarlia,gpyyygonFhlfhorsafteracutemocardialinfaionmcadiumiswerecollectedtodetecthttiindexti.o
7、urandauyrctrtssueteaooc,yopp--terntwnWes.stthTUNrexressofFasFasLCasase8andCasase3bbloResultTheaooticiELandoteinios:pp,,ppyppsasase-sase-rersesllldindexandroteinexressionsofFasFaLC8andCa3wedeceadinificantinaoseGuanxinpp,,ppgyn-n?Heirousthanthoseimodelgrou.Thehihd
8、oseroureceivedthebesteffectthantheothers.Conclusio:GuanxjgppggpnnhtetemocardaaotossreducnaohhFas/FasLathwa.iHeiiibidhyilppibyigpptosistroupyjgKGnx--eynHeioossAMIacuem
