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《不同影像学检查在诊断恶性黑色素瘤转移中的价值比较》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、一72一ChinJLabDiagn,January,2014,Vol18,No.1文章编号:1007—4287(2014)01—0072—05^不同影像学检查在诊断恶性黑色素瘤转移中的价值比较顾慧,徐叉贵(天津医科大学肿瘤医院分子影像与核医学诊疗科,国家肿瘤临床医学研究中心天津市“肿瘤防治“重点实验室,天津300060)摘要:目的探讨不同影像学检查在恶性黑色素瘤转移中临床应用价值。方法回顾性分析经病理证实的82例AJCC分期中Ⅲ~Ⅳ期临床无症状恶性黑色素瘤患者临床资料及确诊后6周内的影像学资料,分别计算各检查方法的
2、真阳性率、假阳性率、特异度及准确率,对影像学可疑转移病灶均行病理组织学活检或临床及影像学随访证实或予以排除。结果82例恶性黑色素瘤患者分别行超声、胸部x线平片、头CT、胸部CT、腹部及盆腔CT、头MRI、PET及PET/CT影像学检查,其中每例患者均行头CT、胸部CT、腹部/盆腔CT,PET,PET/CT检查,总检查次数为548次,其中未发现转移病灶次数为400次(73.0),发现或可疑转移病灶次数为148(27.0)次,其中,84(15.3)次证实为真阳性。影像学总体真阳性率及假阳性率比值为1.3:1(84:64
3、),其中,传统影像学(除PET及PET/CT外)、PET、PET/CT的真阳性率及假阳性率比值为分别为1:1.5(30/46)、2.4:1(24/10)、3.8:1(30/8),特异度分别为77.5%(237/306)、89.6(43/48)、90.9(42/44),准确率分别为69.5(267/384)、81.7(67/82)、87.8(72/82)。除PET/CT与PET比较无统计学意义(P=0.413)外,PET与传统影像学、PET/CT与传统影像学均有统计学意义(P4、规影像学检查在诊断恶性黑色素瘤转移中具有明显优势。关键词:恶性黑色素瘤;PET/CT;诊断中图分类号:R739.5文献标识码:ATocomparethediagnosticvalueofvariousimagingexaminationsforMalignantmelanomaGUHui。XUWen—gui.(De—partmentofMoloculeImagingandNuclearMedicinetoDiagnoseandTreat,TianjinMedicalUniversityCancerIn—stitut5、eandHospital,Tianjin300060,China)Abstract:ObjectiveToassessthediagnosticvalueofvariousimagingexaminationsforMalignantmelanoma.MethodsTostudytheclinicalandimagingdata(6weeksafterfinaldiagnosis)of82PatientswithAmericanJointCommitteeonCancer(AJCC)stageⅢandIVmelan6、omawithsymptomlesssymptomless,respectivelyaccountthetruepositiverate,falsepositiverate,specificity,accuracy.ResultsAtotalof82usingradiographicimaging,includingultrasound,CR,headCT,chestCT,abdomenandpelvicCT,headMRI,PET,PET/CT.Among548stagingexami—nationsin82pa7、tients,27.0wereinitiallyreportedaspositive.15.3ofallexaminationsprovedtrulypositive.Theratiooffalselytotrulypositiveisapproximately1.3:1,TherateofTraditionalimaging,PET,PET/CTwas1:1.5,2.4:1,3.8:1respectively.Thespecificityoftheratewas77.5,89.6,90.9,Theaccuracy8、oftheratewas69.5,81.7,87.8.ExceptthecomparisonofPET/CTandPEThavenosignificance(P=0.413),PETandtradition—alimaging,PET/CTandTraditionalimaginghavebothsignificance(P
4、规影像学检查在诊断恶性黑色素瘤转移中具有明显优势。关键词:恶性黑色素瘤;PET/CT;诊断中图分类号:R739.5文献标识码:ATocomparethediagnosticvalueofvariousimagingexaminationsforMalignantmelanomaGUHui。XUWen—gui.(De—partmentofMoloculeImagingandNuclearMedicinetoDiagnoseandTreat,TianjinMedicalUniversityCancerIn—stitut
5、eandHospital,Tianjin300060,China)Abstract:ObjectiveToassessthediagnosticvalueofvariousimagingexaminationsforMalignantmelanoma.MethodsTostudytheclinicalandimagingdata(6weeksafterfinaldiagnosis)of82PatientswithAmericanJointCommitteeonCancer(AJCC)stageⅢandIVmelan
6、omawithsymptomlesssymptomless,respectivelyaccountthetruepositiverate,falsepositiverate,specificity,accuracy.ResultsAtotalof82usingradiographicimaging,includingultrasound,CR,headCT,chestCT,abdomenandpelvicCT,headMRI,PET,PET/CT.Among548stagingexami—nationsin82pa
7、tients,27.0wereinitiallyreportedaspositive.15.3ofallexaminationsprovedtrulypositive.Theratiooffalselytotrulypositiveisapproximately1.3:1,TherateofTraditionalimaging,PET,PET/CTwas1:1.5,2.4:1,3.8:1respectively.Thespecificityoftheratewas77.5,89.6,90.9,Theaccuracy
8、oftheratewas69.5,81.7,87.8.ExceptthecomparisonofPET/CTandPEThavenosignificance(P=0.413),PETandtradition—alimaging,PET/CTandTraditionalimaginghavebothsignificance(P
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