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1、吗替麦考酚酯治疗难治性狼疮性肾炎的疗效分析及英对临床症状的影响［摘要］目的探讨吗替麦考酚酯治疗难治性狼疮性肾炎的疗效及其对临床症状的影响。方法将难治性狼疮性肾炎患者86例随机分为治疗组和对照组，两纟fl患者均采用常规治疗方法，治疗组在常规治疗基础上，采用吗替麦考酚酯胶囊口服治疗。观察两组治疗前后24h尿蛋白定量、水肿、血压、肉眼血尿、肾功能与不良反应情况。结果经过治疗后，治疗组的尿蛋H转阴、肉眼血尿消失、水肿消退、血压恢复正常、肾功能恢复正常情况明显好于对照纟fi(P<0.05)。治疗组总有效率为88.4%,对照组总有效率为69.8%,治疗纟R
2、明显好于对照纟R(P<0.05)。治疗组痙疮、白细胞减少、月经紊乱等不良反应明显少于对照纟H.(P<0.05)o结论吗替麦考酚酯在难治性狼疮性肾炎屮应用能提高治疗疗效，改善临床症状，且安全性好，值得推广应用。［关键词］吗替麦考酚酯；难治性狼疮性肾炎；临床疗效；临床症状［中图分类号］R692.3［文献标识码］A［文章编号］1673-7210(2012)01(c)-0075-02TheimpactanalysisofclinicalsymptomsandefficacyofMycophenolateMofetilforrefractorylupus
3、nephritisLILeyueDepartmentofNephrology,theSecondPeople'sHospitalofYueyangCity,HifnanProvinee,Yueyang414000,China［Abstract］ObjectiveTodiscusstheimpactofclinicalsymptomsandefficacyofMycophenolateMofetilforrefractorylupusnephritis.Methods86caseswithrefractorylupusnephritiswerer
4、andomlyequallydividedintothetreatmentgroupandthecontrolgroup,patientsoftwogroupsweretreatedwithconventionaltherapy,andthetreatmentgroupwasaddedMycophenolateMofetilCapsulesfortreatment・The24hurinaryprotein,edema,bloodpressure,grosshematuria,renalfunctionandadversereactionsbef
5、oreandaftertreatmentwereobserved.ResultsAftertreatment,theurinaryproteinwasnegative,disappearaneeofgrosshematuria,edema,bloodpressurerecovery,therecoveryofrenalfunctionofthetreatmentgroupweresignificantlybetterthanthecontrolgroup(P<0.05).Thetotaleffectiveratewas88.4%inthetre
6、atmentgroupand69.8%inthecontrolgroup(P<0.05).Tnthetreatmentgroup,theacne,neutropenia,menstrualdisordersandotheradversereactionsweresignificantlylessthanthecontrolgroup(P<0・05).ConelusionMycophenolateMofetilfortreatinglupusnephritisrefractorycanimprovethetreatmcntefficacyofth
7、erapeuticapplications,improvetheclinicalsymptoms,andissafety,whichshouldbewidelyapplied.［Keywords］MycophenolateMofet订；Refractorylupusnephritis;Clinicalefficacy;Clinicalsymptoms难治性狼疮性肾炎(lupusnephritis,LN)是临床最主要的继发性肾脏疾病2—，主要是系统性红斑狼疮累及肾脏引起的一种免疫复合物性肾炎［1］。临床上报道不多，预后比较籀可引起蛋白尿、血尿等严
8、重后果。近年来，随着医学的发展和进步，临床治疗水平有了较大的提高，治疗药物也逐渐增多［2］。但是难治性狼疮性肾炎治疗过程屮还面临着许多问题［3］。本文
