TPPA 阳性TRUST阴性新生儿临床处理探讨.doc

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1、TPPA阳性TRUST阴性新生儿临床处理探讨【中图分类号】R473.72【文献标识码】B【文章编号】1672-3783（2011）12-0071-01【摘要】目的：探讨TPPA及TRUST均阳性的产妇所生TPPA阳性TRUST阴性的新生儿是否需要驱梅治疗。方法：将154例TPPA阳性TRUST阴性新生儿（产妇TPPA及TRUST均阳性），产妇产前未经正规治疗M3例随机分为两组，新生儿给予驱梅治疗的为治疗组（60例），不给予驱梅治疗的为对照1组（53例）。产妇产前经青霉素正规治疗的41例为对照2组。观察各组TPPA转阴情况。结果：3个月TPPA各组转阴率分别为18.3

2、3%、16.98%、17.07%。6个月分别为100%>98.1%、100%o12个月分别为100%、98.1%、100%。12个月时发现对照1组TPPA未转阴的那例新生儿TRUST也出现阳性滴数为1:2。结论：1.对未经治疗梅毒产妇所生TPPA阳性TRUST阴性的新生儿应密切观察其TPPA变化至少18个月。因先天梅毒对新生儿危害极大如有条件都可以给予驱梅治疗。2•妊娠前和妊娠期均经青霉素正规治疗的梅毒产妇所生TPPA阳性TRUST阴性的新生儿基本能排除先天潜伏梅毒。【关键词】产妇，先天潜伏梅毒，新生儿ClinicalAnalysisoftheNeonatesofw

3、ithPositiveTPPAandNegativeTRUSTHengkun,liyingchunyangtangling,hegongjian,[Abstract]ObjectiveToinvestigateiftheneonatesofsyphilisfemalewithpositiveTPPAandpositiveTRUST,whoseTPPAispositiveandTRUSTisnegative,shouldreceiveout-syphilistreartment.Methods154neonatesofsyphilisfemalewithpositiv

4、eTPPAandpositiveTRUSTweredevividedintotwogroups,accordingthepregnantandunpregnantwomenweretreatedoruntreated・theneonatesofreceivingtreatmentwascontrolgroup,andtheneonatesofreceivinguntreatmentwasobservationgroupl.theneonatesofreceivingtreatmentduringpregnantandunpregnantwasobservationg

5、roupII.Theefficencyofeverygroupsduringtreatmentwereobserved・ResultsAfterthreemonthsthenegativeratesofTPPAwere18.33%、16.98%>17.07%respectivelyincontrolgroup,observationgroupI,groupII.AndaftersixmonthsthenegativeratesofTPPAwere100%>98.1%>100%respectivelyincontrolgroup,observationgroupI,g

6、roupII.aftertwelvemonthsthenegativeratesofTPPAwere100%>98.1%>100%respectivelyincontrolgroup,observationgroupIandgroupIIinturn.Intwelvemonths,theneonatesofTRUSTtitrewasl:2incontrolgroup・ConclusionTheneonatesofuntreatedsyphilisfemalewithposi廿veTPPAandpositiveTRUSTwhoseTPPAispositiveandTR

7、USTisnegative,shouldreceiveout-syphilistreartmentforeighteenmonths.Inturn,TheisnoclinicalraUonalefortheneonatesofpregnantandunpregnantsyphilisfemalereceivingregularlytreatmenttoreceiveout-syphilistreartment.[KeysJPregnantfemale;NeonataICongenitalLatentSyphilis；Neonate先天梅毒(CongenitalS