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1、TRUST与TPPA在梅毒诊断和疗效中的应用价值分析罗德维1王开宇1王顺东1周林碧1彭焕文1袁丹2(通讯作者)(1四川省达州市疾病预防控制中心四川达州635002)(2四川省疾病预防控制中心四川成都610041)【摘要】目的:比较梅毒甲苯胺红不加热血清试验(TRUST)与梅毒螺旋体明胶颗粒凝集试验(TPPA)在梅毒诊断和疗效中的应用价值。方法:对1763例性病门诊就诊者、120例非梅毒病例患者、120例健康体检者、100例梅毒治疗患者随访3个月、6个月后的血清标木用TRUST法与TPPA法联合检测,记录结果并分析。结果:1763例
2、性病门诊就诊者中,TRUST检出阳性303份(17.19%),TPPA检出阳性493份(27.96%),TRUST和TPPA均阳性296份(16.79%);120例非梅毒患者的TRUST和TPPA阳性率分别为6.67%和0;120例健康体检者的TRUST和TPPA阳性率分别为0.83%和0;TRUST阳性滴度>l:4、滴度≤l:4的样品TPPA检测结果有差异;100例梅毒治疗患者随访检测结果显示,TPPA均为阳性,TRUST岀现滴度下降或转阴。结论:TRUST和TPPA都是梅毒诊断快速有效的方法,TPPA特异度和灵敏度
3、均明显高于TRUST,但TRUST适合大批量标木筛查,>1.在疗效观察价值上明显好于TPPA,建议对高危人群就诊者、初诊患者使用TRUST和TPPA联合检测,在治患者可只进行TRUST检测。【关键词】梅毒;梅毒甲苯胺红不加热血清试验;梅毒明胶颗粒凝集试验;价值分析【中图分类号】R52【文献标识码】A【文章编号】2095-1752(2016)04-0021-02ValueanalysisofTRUSTandTPPAtestingforsyphilisdiagnosisandcurativeeffectLuoDuoweil,WangK
4、aiyul,WangShundongl,ZhouLinbil,PengHuanwenl,YuanDan2.l.DazhouCenterforDiseaseControlandPrevention,Dazhou,Sichuan635002,China;2.SichuanCenterforDiseaseControlandPrevention,Chengdu610041,China.【Abstract】ObjectiveTocomparetheclinicalvalueofTPPA(treponemapallidumAntibodyp
5、articlesagglutinateexperiment)andTRUST(toluidineredunheatedserumtest)inthediagnosisandtreatmentofsyphilis.Methods1763casesofSTDclinicpatients,120casesofnonsyphilispatients,120casesofnormal,100casesofsyphilispatientstreatedfor3monthsand6monthswereselectedassubjects.The
6、resultsofthejointdetectionwithTRUSTandTPPAwererecordedandcompared.ResultsIn1763casesofSTDclinicpatients,303cases(17.19%)weresyphilispositiveinTRUSTtests,493cases(27.96%)weresyphilispositiveinTPPAtests,and296cases(16.79%)weresyphilispositivebothinTRUSTandTPPAtests.Amon
7、gthe120casesofnonsyphilispatientswithTRUSTandTPPA,thepositiverateswere6.67%and0.Amongthe120casesofnormalwithTRUSTandTPPA,thepositiverateswere0.83%and0.TheTPPAresultsweredifferencesbetweentheTRUSTtiter>1:4samplesandtheTRUSTtiter≤l:4samples.100casesofsyphilispatie
8、ntsfollow-uptestresultsshowedthat,TPPAwaspositive,TRUSTtiterwasdecreasedornegative.ConclusionBoththeTRUSTtestandTPPAtestcoul