新生儿坏死性小肠结肠炎ppt课件.pptx

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1、NeonatalnecrotizingenterocolitisKunyaoYuOutlineRiskfactorBacterial&NECIntestinaldefensemechanismClinicalpresentationBell’sstageTreatmentRiskFactorPrematureLowbirthweight(<1500g)Broad-spectrumantibioticsFeedingBacterial&NECIntestinalbacterialcolonizationintheinfant-Deliverymethod-FeedingDe

2、liveredvaginallyDeliveredviacesareansectionBacterialColonizationLactobacillus,Prevotella,SneathiaStaphylococcus,Corynebacterium,PropionibacteriumBreast-fedFormula-fedBacterialColonizationBifidobacterium,Lactobacillus,StreptococcusBifidobacterium,Staphylococcus,Escherichiacoli,ClostridiaInte

3、stinaldefensemechanismPeristalsisGastricacidProteolyticenzymesIntestinalmucusCellsurfaceglycoconjugatesCell’stightjunctionsImmunologyClinicalpresentationAbdominalsign:distension,vomiting,hematocheziaFeedingintoleranceLethargyTemperatureinstabilityHypotensionImageBell’sstageTreatmentStageI

4、a:-NPOStageIb-IIb/IIIa:-NPO-BroadspectrumantiboticsStageIIIa-IIIb:-Surgery/PeritonealdrainProbiotics-treat?Probiotics-treat?Whatistheoptimalprobioticorganism(s)?Whatistheoptimaladministrationincludingassessmentofwhatpatientsarethebestcandidatesfortreatment?Whatistheoptimalprobioticdose?Wh

5、atisthebesttimingofadministration?Whatisthemostefficaciouslengthoftreatment?THANKYOU