CROSS-LINKED SODIUM CARBOXYMETHYL CELLULOSE-交联羧甲基纤维素钠.pdf

《CROSS-LINKED SODIUM CARBOXYMETHYL CELLULOSE-交联羧甲基纤维素钠.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、CROSS-LINKEDSODIUMCARBOXYMETHYLCELLULOSENewspecificationspreparedatthe59thJECFA(2002),publishedinFNP52Add10(2002),re-publishedwitheditorialcorrectionsinFNP52Add11(2003).Thissubstancewasincludedatthe59thmeetinginthegroupADI“notspecified”formodifiedcelluloses,establishedatthe35thJECFAin198

2、9.SYNONYMSCross-linkedcarboxymethylcellulose,cross-linkedsodiumCMC,cross-linkedCMC,croscarmellosesodium,cross-linkedcellulosegum;INSNo.468DEFINITIONCross-linkedsodiumcarboxymethylcelluloseisthesodiumsaltofthermallycross-linkedpartlyO-carboxymethylatedcellulose.Itismanufacturedbyacidifyin

3、ganaqueoussuspensionofsodiumcarboxymethylcelluloseandheatingthesuspensiontoachievecross-linking.Theproductisthenwashedanddried.ItisalsoproducedduringthemanufactureofsodiumcarboxymethylcellulosebyloweringthepHandheatingtoachievecross-linking.C.A.S.number74811-65-7ChemicalformulaThepolymer

4、scontainsubstitutedanhydroglucoseunitswiththegeneralformula:C6H7O2(OR1)(OR2)(OR3)whereR1,R2,andR3representthefollowinggroups,presentinvaryingproportions-H-CH2COONa-CH2COOHDESCRIPTIONAslightlyhygroscopic,whitetogreyish-white,odourlesspowderFUNCTIONALUSESTablettingagentCHARACTERISTICSIDENT

5、IFICATIONSolubility(Vol.4)Practicallyinsolubleinacetone,inethanolandintolueneColourreactionAdd1gofthepowderedsampleto50mlwater,whilestirringtoproduceauniformdispersion.Dilute1mlofthismixturewith1mlofwaterinasmalltesttubeandadd5dropsof1-naphtholTS.Inclinethetesttube,andcarefullyintroduced

6、ownthesideofthetube2mlofsulfuricacidsothatitformsalowerlayer.Ared-purplecolourdevelopsattheinterface.PrecipitateformationMix1gofthepowderedsamplewith100mlofsolutioncontaining4mg/kgofmethyleneblueinwaterandallowtosettle.Thesubstanceabsorbsmethyleneblueandsettlesasablue,fibrousmass.Testfor

7、sodium(Vol.4)PassestestPURITYpH(vol.4)Notlessthan5.0andnotmorethan7.0(1in100suspensioninwater)Lossondrying(Vol.4)Notmorethan6%(105o,3h)Sulfatedash(Vol.4)Notlessthan14.0%andnotmorethan28.0%onthedriedbasis(2gofsample)Water-solublesubstancesNotmorethan10%SeedescriptionunderT