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ID:52766673
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时间:2020-03-30
《CROSS-LINKED SODIUM CARBOXYMETHYL CELLULOSE-交联羧甲基纤维素钠.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、CROSS-LINKEDSODIUMCARBOXYMETHYLCELLULOSENewspecificationspreparedatthe59thJECFA(2002),publishedinFNP52Add10(2002),re-publishedwitheditorialcorrectionsinFNP52Add11(2003).Thissubstancewasincludedatthe59thmeetinginthegroupADI“notspecified”formodifiedcelluloses,establishedatthe35thJECFAin198
2、9.SYNONYMSCross-linkedcarboxymethylcellulose,cross-linkedsodiumCMC,cross-linkedCMC,croscarmellosesodium,cross-linkedcellulosegum;INSNo.468DEFINITIONCross-linkedsodiumcarboxymethylcelluloseisthesodiumsaltofthermallycross-linkedpartlyO-carboxymethylatedcellulose.Itismanufacturedbyacidifyin
3、ganaqueoussuspensionofsodiumcarboxymethylcelluloseandheatingthesuspensiontoachievecross-linking.Theproductisthenwashedanddried.ItisalsoproducedduringthemanufactureofsodiumcarboxymethylcellulosebyloweringthepHandheatingtoachievecross-linking.C.A.S.number74811-65-7ChemicalformulaThepolymer
4、scontainsubstitutedanhydroglucoseunitswiththegeneralformula:C6H7O2(OR1)(OR2)(OR3)whereR1,R2,andR3representthefollowinggroups,presentinvaryingproportions-H-CH2COONa-CH2COOHDESCRIPTIONAslightlyhygroscopic,whitetogreyish-white,odourlesspowderFUNCTIONALUSESTablettingagentCHARACTERISTICSIDENT
5、IFICATIONSolubility(Vol.4)Practicallyinsolubleinacetone,inethanolandintolueneColourreactionAdd1gofthepowderedsampleto50mlwater,whilestirringtoproduceauniformdispersion.Dilute1mlofthismixturewith1mlofwaterinasmalltesttubeandadd5dropsof1-naphtholTS.Inclinethetesttube,andcarefullyintroduced
6、ownthesideofthetube2mlofsulfuricacidsothatitformsalowerlayer.Ared-purplecolourdevelopsattheinterface.PrecipitateformationMix1gofthepowderedsamplewith100mlofsolutioncontaining4mg/kgofmethyleneblueinwaterandallowtosettle.Thesubstanceabsorbsmethyleneblueandsettlesasablue,fibrousmass.Testfor
7、sodium(Vol.4)PassestestPURITYpH(vol.4)Notlessthan5.0andnotmorethan7.0(1in100suspensioninwater)Lossondrying(Vol.4)Notmorethan6%(105o,3h)Sulfatedash(Vol.4)Notlessthan14.0%andnotmorethan28.0%onthedriedbasis(2gofsample)Water-solublesubstancesNotmorethan10%SeedescriptionunderT
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