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时间:2020-03-23
《羧甲基纤维素钠交联微球的制备及性能研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第43卷第3期塑料工业CHINAPLASTICSINDUSTRY·41·2015年3月聚乙烯醇/羧甲基纤维素钠交联微球的制备及性能研究.谭真,张雷,张倩(四川大学高分子科学与工程学院,四川成都610000)摘要:采用反相悬浮法制备聚乙烯醇(PVA)/羧甲基纤维素钠(CMC-Na)交联微球。通过正交法探讨了戊二醛用量、原料配比、催化剂用量以及反应温度对产率和平衡溶胀率的影响;采用红外光谱、扫描电镜对微球的化学组成和表面形貌进行分析,并研究了微球在不同pH条件下的溶胀行为。正交试验结果表明,最优实验方案下微球产率达到88.89%。红外光谱和扫描电镜测试结果表
2、明,反应生成了PVA/CMC微球,微球球形度和分散性优良,粒径分布均匀,微球平均粒径为195Ixm。溶胀性能研究表明,在酸性环境中微球先溶胀后退溶胀;在碱性环境中微球不断溶胀直到溶胀平衡,且在碱性环境中微球的平衡溶胀率1.75远大于在酸性环境中的平衡溶胀率0.89,微球表现出pH敏感性。根据微球的pH敏感性,有望作为结肠靶向药物载体材料。关键词:聚乙烯醇;羧甲基纤维素钠;微球;反相悬浮聚合;溶胀性能;pH敏感性DOI:10.3969/j.issn.1005-5770.2015.03.002中图分类号:TQ325.9文献标识码:A文章编号:1005-577
3、0(2o15)03—004l一04PreparationandPropertiesofPolyvinylAlcohol/SodiumCarboxymethylCelluloseCrosslinkingMicrospheresTANZhen,ZHANGLei,ZHANGQian(CollegeofPolymerScience&Engineering,SichuanUniversity,Chengdu610000,China)Abstract:Asetofpolyvinylalcohol(PVA)/sodiumearboxymethylcellulose(C
4、MC-Na)crosslinkingmicrosphereswerepreparedbyinversesuspensionpolymerization.Theeffectsontheproductyieldandtheequilibriumswellingdegreewerediscussedbyanorthogonalexperimentinwhichglutaricdialdehydedosage,rawmaterialsratio,catalystamountandreactiontemperaturewereselectedasthemainfa
5、ctors.Fouriertransforminfraredspectrometer(FFIR)andscanningelectronicmicroscopy(SEM)wereappliedtocharacterizethestructureandmorphologyofthemicrospheres,andtheswellingbehaviorofmicrosphereswerediscussedatdifferentpHvalues.Theorthogonalresultsdemonstratedthattheyieldofthemicrospher
6、eswas88.89%atoptimalconditions.TheresultsofIRandSEMshowedthatthePVA/CMCmicrosphereswereproducedbythereactionwithgoodsophericityanddispersityandtheuniformdistributionofparticlesizewithameanparticlesizeof195m.Theswellingbehaviorofmicrospherewasdeswellingafterswellingatacidicbuffer.
7、Ontheotherhand,themierospherewasswellinguntilequilibriumswellingatalkalinebufferwiththefarhigherswellingdegree(1.75)thanthatofthemicrosphereatthealkalinebuffer(0.89),whichshowedthemicrospherewaspHsensitive.Themicrospherewasexpectedasacarriermaterialofthecolontargetingdrugbecauseo
8、fitspHsensitivity.Keywords:PolyvinylAlco
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