CYCLOHEXYLSULFAMIC ACID-环己基氨基磺酸、甜蜜素.pdf

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1、CYCLOHEXYLSULFAMICACIDPreparedatthe46thJECFA(1996),publishedinFNP52Add4(1996)supersedingspecificationspreparedatthe24thJECFA(1980),publishedinFNP17(1980)andinFNP52(1992).Metalsandarsenicspecificationsrevisedatthe57thJECFA(2001).AgroupADIof0-11mg/kgbwforcyclamicacidanditscalciumandsod

2、iumsalts(ascyclamicacid)wasestablishedatthe26thJECFA(1982)SYNONYMSCyclamicacid,INSNo.952DEFINITIONChemicalnamesCyclohexylsulfamicacid,cyclohexanesulfamicacidC.A.S.number100-88-9ChemicalformulaC6H13NO3SStructuralformulaFormulaweight179.24AssayNotlessthan98.0%andnotmorethan102.0%onthed

3、riedbasisDESCRIPTIONPracticallycolourless,whitecrystallinepowderFUNCTIONALUSESSweetenerCHARACTERISTICSIDENTIFICATIONSolubility(Vol.4)Solubleinwater,andinethanolPrecipitateformationAcidifya2%solutionwithhydrochloricacid,add1mlofbariumchlorideTSandfilterifanyhazeorprecipitateforms.Toth

4、eclearsolutionadd1mlofa10%solutionofsodiumnitrite.Awhiteprecipitateforms.PURITYLossondrying(Vol.4)Notmorethan1.0%(105º,1h)Cyclohexylamine(Vol.4)Notmorethan10mg/kgTransfer25gofthesampleintoa100mlvolumetricflaskcontaining20mlofwater,mix,andadd60mlofsodiumhydroxideTS.AddsodiumhydroxideT

5、S,ifnecessary,tomakethesolutionalkalinetolitmus.Dilutetovolumewithwater,andmix.Usethissolutionasthetestpreparation.DicyclohexylamineNotmorethan1mg/kg(Vol.4)Lead(Vol.4)Notmorethan1mg/kgDetermineusinganatomicabsorptiontechniqueappropriatetothespecifiedlevel.Theselectionofsamplesizeandm

6、ethodofsamplepreparationmaybebasedontheprinciplesofthemethoddescribedinVolume4,“InstrumentalMethods.”METHODOFTransferabout350mg,accuratelyweighed,intoa250mlflask.DissolveASSAYthesamplein50mlofwater,addphenolphthaleinTS,andtitratewith0.1Nsodiumhydroxide.Eachmlof0.1Nsodiumhydroxideiseq

7、uivalentto17.82mgofC6H13NO3S.