CALCIUM CYCLAMATE-环己基氨基磺酸钙.pdf

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1、CALCIUMCYCLAMATEPreparedatthe46thJECFA(1996),publishedinFNP52Add4(1996)supersedingspecificationspreparedatthe24thJECFA(1980),publishedinFNP17(1980).Metalsandarsenicspecificationsrevisedatthe63rdJECFA(2004).AgroupADIof0-11mg/kgbwforcyclamicacidanditscalciumandsodiumsalts

2、(ascyclamicacid)wasestablishedatthe26thJECFA(1982)SYNONYMSINSNo.952DEFINITIONChemicalnamesCalciumcyclohexylsulfamate,calciumcyclohexanesulfamateC.A.S.number139-06-0ChemicalformulaC12H24CaN2O6S2·2H2OStructuralformulaFormulaweight432.57AssayNotlessthan98.0%andnotmorethan1

3、01.0%ontheanhydrousbasisDESCRIPTIONWhitecolourlesscrystalsorcrystallinepowder.Approximately30timessweeterthansucroseFUNCTIONALUSESSweetenerCHARACTERISTICSIDENTIFICATIONSolubility(Vol.4)Solubleinwater,sparinglysolubleinethanolPrecipitateformationTo10mlofa1in100solutionof

4、thesampleadd1mlofhydrochloricacidTS,mix,add1mlofbariumchlorideTS.Thesolutionremainsclear,butupontheadditionof1mlsodiumnitriteTS,awhiteprecipitateisformedTestforcalcium(Vol.4)PassestestPURITYLossondrying(Vol.4)oNotlessthan6.0%andnotmorethan9.0%(140,2h)CyclohexylamineNotm

5、orethan10mg/kg(Vol.4)Transfer25gofthesampleintoa100mlvolumetricflask,dissolveinwater,dilutetovolumewithwater,andmix.Usethissolutionasthetestpreparation.DicyclohexylamineNotmorethan1mg/kg(Vol.4)Lead(Vol.4)Notmorethan1mg/kgDetermineusinganatomicabsorptiontechniqueappropri

6、atetothespecifiedlevel.TheselectionofsamplesizeandmethodofsamplepreparationmaybebasedontheprinciplesofthemethoddescribedinVolume4,“InstrumentalMethods.”METHODOFDissolveabout0.4gofthesampleaccuratelyweighed,inamixtureof50mlASSAYofwaterand5mlofdilutehydrochloricacidTSandt

7、itratewith0.1Msodiumnitrite.Addthelastmloftitrantdropwiseuntilabluecolourisproducedimmediatelywhenaglassroddippedintothetitratedsolutionisstreakedonapieceofstarchiodidetestpaperoralternativelytheendpointmaybedetectedelectro-metrically.Whenthetitrationiscomplete,theend-p

8、ointisreproducibleafterthemixturehasbeenallowedtostandfor1min.Eachmlof0.1Msodiumnitriteisequivalentto19.83mgof