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1、血管内皮生长因了受体表达水平与胃癌临床病理学特征的关系［摘要］目的：探讨血管内皮生长因了受体与胃癌临床病理学特征关系。方法：对53例胃癌切除患者胃癌纟R织细胞，应用免疫纟R织化学(Immunohistochemistry,IHC)技术，分别检测胃癌组织的血管内皮生长因•了受体(VascularEpidermalGrowthFactorReceptor,VEGFR)VEGFRkVEGFR2、VEGFR3在胃癌组织屮的表达水平。结果：在不同肿瘤浸润深度及淋巴转移程度的胃癌组织屮：VEGFR1的表达差界无统计学意义(P〉0.05),VEGFR
2、2的表达并异有统计学意义(P均＜0.05),VEGFR3的表达并异有统计学意义(P均＜0.05),且在胃癌组织屮VEGFR3的表达量随着浸润深度、局部区域淋巴结转移数的增加而逐渐递增。结论：在不同肿瘤浸润深度及淋巴转移稈度的胃癌组织屮，VEGFR2的表达有差异性，VEGFR3的表达亦有斧异性，且VEGFR3的表达随着浸润深度、局部区域淋巴结转移数的增加而递增，提示VEGFR3在胃癌组织屮的表达量可以作为疾病严重程度的一个量化指标，为研究胃癌的治疗新靶点提供了进一步的理论依据。［关键词］血管内皮生长因子受体；胃癌；临床病理学特征［中图分类
3、号］R735.2E文献标识码］A［文章编号11673-7210(2011)08(a)-016-04AssociationbetweenvascularepidermalgrowthfactorreceptorandclinicopathologiccharactersingastriccancerYANGJingl,JINGZaiping2*1.Shanghai7thPeople'sHospital,Shanghdi200137,China;2.Chang^hengHospital,theSecondMilitaryMedicalUni
4、versity,InstituteofVascularSurgeryofPeople'sLiberationArmy,Shanghai200433,China［Abstract］Objective:ToexploretherelationshipbetweentheexpressionofVEGFRandclinicopsthologiccharactersintumortissues.Methods:53patientswithgastriccancerwererecruitedandinmiunohistochemistry(Imm
5、unohistochemistry,THC)techniqueswereusedtodetecttheexpressionlevelsofVEGFR1,VEGFR2,VEGFR3ingastriccancertissue.Results:TheexpressionlevelsofVEGFR1ingastriccancertissuewereunrelatedwithtumorinvasionandlymphnodemetastasis(P〉0・05);TheexpressionlevelsofVEGFR2ingastriccancert
6、issuewereassociatedwithtumorinvasionandlymphnodemetastasis(al1P〈0・05);TheexpressionlevelsofVEGFR3ingastriccancertissuewererelatedwithtumorinvasionandlymphnodemetastasiscorrelated(allP〈0・05),moreover,itincreasedgraduallywiththeextentofdepthofinvasionandthenumberoflymphnod
7、emetastasis.Cone1usion:VEGFR2expressionlevelsingastriccancertissuewererelatedwithtumorinvasionandlymphnodemetastasis;VEGFR3expressionlevelsingastriecancertiswuecorrelatedwithtumorinvasionandlymphnodemetastasis,anditincreasedwiththeextentofdepthofinvasionandthenumberoflym
8、phnodemetastasis,whichsuggestingthatVEGFR3expressionlevelsingastriccancertissuemightbeusedasapotentialm
