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ID:52457386
大小:4.93 MB
页数:56页
时间:2020-04-07
《NKT细胞淋巴瘤周剑峰.ppt》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、NK细胞增殖性疾病同济医院血液内科周剑峰2015年06月07日T和NK细胞肿瘤的分类:WHO2008WHO2008:thematureT-cellandNK-cellneoplasmsT-cellprolymphocyticleukemiaT-celllargegranularlymphocyticleukemiaChroniclymphoproliferativedisorderofNK-cells*AggressiveNKcellleukemiaSystemicEBV+ T-celllympho
2、proliferativediseaseofchildhood(associatedwithCAEBV)Hydroavacciniforme-likelymphomaAdultT-cellleukemia/lymphomaExtranodalNK/Tcelllymphoma,nasaltypeEnteropathy-associated T-celllymphomaHepatosplenicT-celllymphomaSubcutaneouspanniculitis-likeT-celllympho
3、maMycosisfungoidesSézarysyndromePrimarycutaneousCD30+ T-celllymphoproliferativedisorderLymphomatoidpapulosisPrimarycutaneousanaplasticlarge-celllymphomaPrimarycutaneousaggressiveepidermotropicCD8+ cytotoxicT-celllymphoma*Primarycutaneousgamma-deltaT-ce
4、lllymphomaPrimarycutaneoussmall/mediumCD4+ T-celllymphoma*PeripheralT-celllymphoma,nototherwisespecifiedAngioimmunoblasticT-celllymphomaAnaplasticlargecelllymphoma(ALCL),ALK+Anaplasticlargecelllymphoma(ALCL),ALK−*2001WHO2008WHOCommentsAngioimmunoblasti
5、cLymphomaAngioimmunoblasticLymphomaDefinitionoforigincellAnaplasticLargeCellLymphoma2variantsbasedonALK(+/-)expressionPrognosticimportanceUnspecifiedPeripheralT-cellLymphomaPeripheralT-cellLymphomasnotOtherwiseSpecified3variants:lymphoepitelioidlymphom
6、a,Tzonelymphoma(2001WHO)andfollicularlymphoma(2008WHO)T/NK-celllymphoma,nasaltypeT/NK-celllymphoma,nasaltypeNochangesEntheropathy-associatedT-celllymphomaEntheropathy-associatedT-celllymphomasTwovariants:classicalandmonomorphictypeswithgeneticchangesco
7、mmontobothHepatosplenicT-celllymphomaHepatosplenicT-celllymphomaNochangesSubcutaneouspanniculitis-likeT-celllymphomaSubcutaneouspanniculitis-likeT-celllymphomaOnlyabandassociatedwithautoimmunedisorderMycosisfungoidesMycosisfungoidesNewstagingandnewinfo
8、rmationaboutpathogenesisSézarysyndromeSézarysyndromeNewmarkersPrimarycutaneousanaplasticlargecelllymphomaPrimarycutaneousanaplasticlargecelllymphomaRecognitionofCD8+casesLymphomatoidpapulosisLymphomatoidpapulosisThreehistologicaltypesPr
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