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1、米索前列醇不同给药途径用于预防剖宫产术出血临床观察doi:10.3969/j.issn.1007-614x.2014.12.28摘要目的:探讨通过宫内给药、直肠给药、口服给药途径给予米索前列醇对预防剖宫产术出血产妇的临床疗效。方法:2013年1月-2014年1月收治分娩产妇666例,随机分成宫内给药组、直肠给药组和口服组,各222例。3组均在胎儿娩出后宫体注射催产素20ug,分别经采取宫内给药、直肠给药、口服给药途径给予米索前列醇400ug治疗。结果:宫内给药组术中出血量、产后2小时平均出血量、24小时平均出血量分别为(125・8±42・1)ml、(199.
2、8土39.6)ml>(229.6±39.2)ml,直肠给药组术中出血量、产后2小时平均出血量、24小时平均出血量分别为(187.8±48.5)ml>(225.3土61.2)ml.(305.3±61.2)ml,口服组术中出血量、产后2小时平均出血量、24小时平均出血量分别为(131・2±40・9)ml、(205・8±42・1)ml、(258.9±55.1)ml;术中出血量方面,宫内给药组和口服组明显优于宜肠给药组(卩0.05);24小时平均出血量方面,宫内给药组和口服组明显优于直肠给药组(P〈0・05),宫内给药组出血量略低于口服组;宫内给药组发生产后出血1例
3、,出血发生率0.045%,直肠给药组发生产后出血4例,出血发生率1.8%,口服组发生产后出血2例,出血发生率0.045%,直肠给药组发生产后出血1例,出血发生率0.9%,3组比较差异有统计学意义(卩〈0・05)。结论:宫内给予米索前列醇是预防剖宫产术出血的最佳给药途径。关键词剖宫产米索前列醇宫内给药直肠给药口服给药TheclinicalobservationofdifferentroutesofadministrationofmisoprostolforthepreventionofcesareansectionhemorrhageWangZhaofenDe
4、partmentofObstetricsandGynecology,theTraditionalChineseMedicineHospitalofYanshanCount,WenshanState,Yunnan663100AbstractObjective:Toinvestigatetheclinicalcurativeeffectofintrauterineadministration,rectaladministration,oraladministrationofmisoprostolforthepreventionofcesareansectionh
5、emorrhage・Methods:666casesofpregnantwomenwereselectedfromJanuary2013toJanuary2014.Theywererandomlydividedintotheintrauterineadministrationgroup,therectaiadministrationgroupandtheoralgroupwith222casesineach・Threegroupsweregiven20uguterineoxytocininjectionafterthedeliveryoffetus.Thre
6、egroupswererespectivelygiven400ugmisoprostolbytheintrauterineadministration,rectaladministration且ndoraladministration.Results:Tntheintrauterineadministrationgroup,theamountofintraoperativebleeding,theaverageamountofbleedingofpostpartum2hours,theaverageamountofbleedingof24hourswere1
7、25.8+42.1ml,199.8±39.6ml,229.6土39.2ml.Intherectaladministrationgroup,theamountofintraoperativebleeding,theaverageamountofbleedingofpostpartum2hours,theaverageamountofbleedingof24hourswere187.8+48.5ml,225.3±61.2ml,305.3+61.2ml.Intheoralgroup,theamountofintraoperativebleeding,theaver
8、ageamountofbleedingofpostp