环糊精在锌铝类水滑石中插层的制备和性能.pdf

《环糊精在锌铝类水滑石中插层的制备和性能.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、物理化学学报(WuliHuaxueXuebao)558Acta尸．-Chim．．2016，32(2)，558-564February[Article]doi：10．3866／PKU．WHXB201511271www．whxb．pku．edu．cn毒死蜱，环糊精在锌铝类水滑石中插层的制备和性能刘洁翔任纪辉’赵乔’石婷静’刘志芳’罗诏’张晓光t’f河北工业大学化工学院，天津300130；南开大学化学学院，天津300071)摘要：以层状锌铝类水滑石(ZAL)为主体，分别以磺丁基醚-』B一环糊精(SBECD)4q

2、]羧甲基一JB-环糊精(CMCD)包结毒死蜱(CPF)为客体分子，分别在乙醇和M甲基吡咯烷酮(NMP)溶剂条件下制备zAL—SBECD—CPF和ZAL—CMCD．CPF插层材料，采用X射线粉末衍射(XRD)、傅里叶变换~#b(FT-IR)光谱和热重-差热分析(TG-DTA)对其结构和热稳定性进行表征。结果表明，CPF／SBECD和CPF／CMCD均可成功在ZAL中插层，且在NMP溶剂条件下合成样品的衍射峰强度要强；插层CPF分子有较高热稳定性。此外，还对ZAL—SBECD-CPF和ZAL．CMCD．CPF

3、在pH=5．0，6．8的环境条件下的释放行为进行研究和对比。结果发现，ZAL．SBECD-CPF样品几乎没有缓释性能，而ZAL．CMCD．CPF有一定的缓释性能，这与客体分子在层间排布方式不同有关。两种样品在pH=6．8条件下的释放百分率均高于pH=5，0，这与释放环境和环糊精(CD)分子结构密切相关。ZAL．CMCD．CPF的释放行为可很好的用二级动力学方程和parabolicdiffusion模型来描述，说明药物客体分子释放主要受扩散过程控制。研究结果将有助于开发ZAL．CMCD．CPF在农药制剂方面

4、的应用价值。关键词：锌铝类水滑石；环糊精；毒死蜱；释放性能中图分类号：O641PreparationandCharacterizationofChlorpyrifos／CyclodextrinComplexIntercalationintoZnAI-LayeredDoubleHydroxideLIUJie-Xiang’’RENJi—Hui’ZHAOQiao’SHITing—Jing’LIUZhi—Fang’LUOZhao’ZHANGXiao—Guang1(SchoolofChemicalEngineeri

5、ng，HebeiUniversityofTechnology,Tianjin300130，R．China；CollegeofChemistry,NankaiUniversity,Tianjin300071，R．China)Abstract：Chlorpyrilos(CPF)wasfirstlyincludedjnsulfonatedhydroxyethy1．口．cyclodextrin(SBECD)andcarboxymethy1．-cyclodextrin(CMCD)inanethanoIor1．met

6、hy1．2．pyrrolidinone(NMP)solvent．1nclusioncomplexes(CPF，SBECDandCPF，CMCD)werethenintercalatedintothegalleriesofZnAI．1ayereddoublehydroxides(zAL)tosynthesizeZAL—SBECD．CPFandZAL．CMCD．CPFintercalatedmaterials．Thestructureandthermalstabilityofnanohybridswerech

7、aracterizedbypowder×．raydiffractionfXRD)。Fouriertransforminfl-ared(FT-IR)spectroscopy,andthermalgravimetricanddiferentiaIthermaIanalysis(TG．DTA)．TheresultsshowedthatbOthCPF／SBECDandCPF／SBECDweresuccessfullyintercalatedintheinterlayer．Thesamplespreparedint

8、heNMPsolventhadastrongerdifractionpeakintensitythanthosepreparedwithethanoI．TheintercalatedCPFmoleculeshadahighthermaIstability．Furthermore．thereleasebehaviorsofCPFfr0mZALSBECD-CPFandZAL．CMCD．CPFnanohybndswereinvest