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1、贝那普利联合保肾康治疗慢性肾小球肾炎的临床疗效分析及其价值研究【摘要】目的:探讨贝那普利联合保肾康治疗慢性肾小球肾炎的临床疗效及其价值。方法:选取2013年12月-2015年12月本院收治的已明确诊断为原发性慢性肾小球肾炎180例患者作为研究对象,按照随机数字表法将其分为对照组92例和观察组88例o对照组给予盐酸贝那普利片口服治疗,观察组给予盐酸贝那普利片+保肾康联合治疗,4周为一疗程,两组均连续治疗4个疗程。观察并比较两组治疗前后血压、24h尿蛋白定量情况及总有效率。结果:治疗前,对照组血压(139+12)/(78±7)mmHg,观察组(138±11)/(80±9)mmHg,比较差异
2、无统计学意义(P>0.05);治疗后,对照组血压(136±10)/(76±7)mmHg,观察组(135±10)/(78±8)mmHg,两组血压均较治疗前有所降低,但比较差异均无统计学意义(P>0.05),且两组间比较差异亦无统计学意义(P>0.05)o治疗前,对照组24h尿蛋白定量为(1.87±0.62)g,观察组24h尿蛋白定量为(1.92±0.67)g,比较差异无统计学意义(P>0.05);治疗后,对照组24h尿蛋白定量为(0.89±0.45)g,观察组24h尿蛋白定量为(0.61+0.41)g,两组24h尿蛋白定量均较治疗前明显降低,且治疗后观察组明显低于对照组,比较差异均有统计
3、学意义(P【关键词】盐酸贝那普利片;保肾康;慢性肾小球肾炎;临床疗效;价值AnalysisandResearchonClinicalEfficacyandValueofBenazeprilCombinedwithPiperazineFerulateTabletsintheTreatmentofChronicGlomerulonephritis/XIEGuang-jie,YIFu-gan.//MedicalInnovationofChina,2016,13(27):049-052【Abstract】Objective:Toexploretheclinicalefficacyandvalu
4、eofBenazeprilcombinedwithPiperazineFerulateTabletsinthetreatmentofchronicglomerulonephritis.Method:FromDecember2013toDecember2015,180casesofclearlydiagnosedtosufferfromprimarychronicglomerulonephritisinourhospitalwereselectedastheresearchobjects,theyweredividedintothecontrolgroupof92casesandtheo
5、bservationgroupof88casesaccordingtotherandomnumbertablemethod.ThecontrolgroupwasgivenoralBenazeprilHydrochlorideTabletstherapyandtheobservationgroupwasgivenBenazeprilHydrochlorideTabletscombinedwithPiperazineFerulateTabletstherapy,4weeksfor1coursesoftreatmentandtwogroupswerecontinuoustreatmentof
6、4courses.Thebloodpressure,24hurineproteinquantitybeforeandaftertreatmentandtotaleffectiverateoftwogroupswereobservedandcompared.Result:Beforetreatment,thebloodpressureinthecontrolgroupwas(139±12)/(78±7)mmHgandthatoftheobservationgroupwas(138±11)/(80±9)mmHg,thedifferencewasnotstatisticallysignifi
7、cant(P>0.05)・Aftertreatment,thebloodpressureinthecontrolgroupwas(136±10)/(76±7)mmHgandthatoftheobservationgroupwas(135+10)/(78±8)mmHg,thebloodpressureintwogroupswaslowerthanbeforetreatment,buttherewasnosignificantdifference,