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1、百令胶囊对同期放化疗鼻咽癌患者免疫调节作用的临床研究［摘要］目的探讨白令胶囊对同期放化疗鼻咽癌患者的免疫调节作用。方法回顾性分析2010年12月〜2014年12月我院收治的80例鼻咽癌患者临床资料，其中采用同期放化疗方案治疗患者40例（对照组），联合采用白令胶囊和同期放化疗治疗患者40例（实验组）。对比观察两组患者治疗前后及随访3个月、6个月的外周血T细胞亚群水平与免疫球蛋白水平，以及两组患者的不良反应情况。结果治疗后及随访3个月、6个月实验组CD4+水平、CD8+水平和CD4+/CD8+水平均显著优于对照组（P〈0・05）；治疗后及随访3个月、
2、6个月实验组IgG水平、IgA水平和IgM水平均显著高于对照组（P<0.05）；实验组骨髓抑制率（27.5%）,口腔、咽部黏膜充血糜烂（20.0%）比例显著低于对照组（52.5%、47.5%）,差异有统计学意义（P〈0.05）。结论同期放化疗鼻咽癌患者口服百令胶囊，可增强其机体免疫功能，减轻放化疗不良反应，提高疗效，临床推广价值显著。［关键词］鼻咽癌;百令胶囊;同期放化疗；免疫水平；不良反应［中图分类号］R739.6［文献标识码］A［文章编号］1674-4721（2016）10(a)-0091-04ClinicalstudyofBailingCa
3、psuleonmmunomodulatoryeffectsconcurrentradiochemotherapj^forpatientswithnasopharyngealcareinomaYANGJingDepartmentofOncology,theFirstAffiliatedHospitalofGannanMedicalCollegeinJiangxiProvince,Ganzhou341000,China.Abstract]ObjectiveToexploretheeffectofBailingCapsuleonimmunefuncti
4、onconcurrentradiochemotherapyforpatientswithnasopharyngealcarcinomainthesameperiod.MethodsTheclinicaldataof80patientswithnasopharyngealcarcinomawereretrospectivelyanalyzedinourhospitalfromDecember2010toDecember2014,40cases(controlgroup)weretreatedwithconcurrentradiotherapyand
5、chemotherapy,while40cases(experimentalgroup)weretreatedwiththecombinationofBailingCapsuleandconcurrentradiotherapyandchemotherapy.PeripheralbloodTlymphocytesubsetsandimmunoglobulinlevelsbeforetreatment,aftertreatmentandfollow-upfor3months,6months,adversedrugreactionswerecompa
6、redbetweentwogroups.ResultsAftertreatment,follow-up3monthsand6months,CD4+,CD8+andCD4+/CD8+leveloftheexperimentalgroupwerebetterthanthoseofthecontrolgroup(P<0.05)・Aftertreatment,follw-up3monthsand6months,IgG,TgAandTgM1eveloftheexperimentalgroupwerebetterthanthoseofthecontrolgr
7、oup(P<0.05)・Intheexperimentalgroup,theratioofbonemarrowsuppression(27.5%),oralcavityandpharyngealmucosalcongestionanderosion(20.0%)wassignificantlylowerthanthatofthecontrolgroup(52.5%,47.5%)respectively(P<0.05).ConclusionConcurrentradiotherapyandchemotherapycanenhancetheimmun
8、efunction,reducesideeffectsofradiotherapyandchemotherapy,improvethet
