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1、CombinedOperationModalityvs.ImatinibMesylateAloneforPatientswithRecurrentorMetastaticGastrointestinalStromalTumors:theRandomizedCOMVIATrialDUChunyam,ZHOUYe】，SONGChun2,WANGYongpeng2,JIEZhigang3,LIANGXiaobosHEYulongsCAOHuie,YANZhongshu?,SHIYingqiangi(1・Dep
2、artmentofGastricCancerandSoftTissueSurgery,CancerCcnle几FudanUniversity,ShangHai200237;2.DepartmentofColorectalSurgery,LiaoningCancerHospital&Institute,ShenYang110()42;3.DepartmentofGeneralSurgery,theFirstAffiliatedHospitalofNanchangUniversity,NanChang300
3、006;4.DepartmentofColorectalCancer,ShanxiCancerHospital,TaiYuan030013;5・DepartmentofGastrointestinal&PanceaticSurgery,theFirstAffiliatedHospitaLSunYat-senUniversity,GuangZhou510080;6.DepailmenlofGeneralSurgery,RenjiHospital,ShanghaiJiaolongUniversityScho
4、olofMedicine,ShangHai200127;7.DepartmentofGastrointestinalSurgery,XiangyaHospital,CentralSouthUniversity,ChangSha410008)Abstract:Objectives:GaslrointeslinalStromalTumors(GISTs)arethemostcommonmesenchymaltumorsofthegastrointestinaltract.ForadvancedGISTpat
5、ientswhoarerespondingtoimatinibmesylate,theroleofsurgeryhasnotbeenformallydemonstrated.Therefore,thismulticenter,randomized,controlledtrialwasdesignedtoassesswhethersurgeriestotreatresidualdiseaseforpatientswithrecurrent/metastaticGISTsrespondingtoimatin
6、ibmesylate(IM)improvesprogressionfreesurvival(PFS)comparedwithIMtreatmentalone・Methods:Between3and12monthsafterstartingmolecular-targetedtherapywithIMforrecurven〔/me{as【alicGISTs,eligiblepatientswererandomizedtotwoarms:ArmA(surgeryforresidualdisease)andA
7、rmB(IMtreatmentalone)・InArmA(19pts),surgerywasperiormedtoremoveresidualmacroscopiclesionsascompletelyaspossible,andIMtreatmenlcontinuedaftersurgery.InArmB(22pls),IMwasgivenaloneatadoseof400mgperdayuntildiseaseprogiession.TheprimaryendpointwasPFS,measured
8、fromthedaleIMstarts.ThisstudyisregisteredintheChiCTRregistrywithlheIDnumberChiCTR-TRC-00000244.Results:Thisrandomizedtrialwasclosedearlyduetopooraccrual.Only41patientswereenrolledasopposedto210planned・Afteramedianfollow-up
