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1、S449thICEIDAbstracts/JournalofEquineVeterinaryScience32(2012)S3-S95morerapiddevelopmentofthelarvae,reducedresidualcharacteristicswithpotentialgenomicvariationsbetweeneffectoftreatmentoracombinationofboth.Thesedataporcineandequineisolates.showanalterationfr
2、omthesituationaswasfoundwhenivermectinwasintroducedandcanbeconsideredasanearlywarningforthedevelopmentofivermectinresistance.EvidenceofhostadaptationinLawsoniaintracellularisinfections1221F.A.Vannucci,N.Pusterla,S.M.Mapes,M.Kelley,and1C.J.Gebhart1Departmen
3、tofVeterinaryandBiomedicalSciences,CollegeofVeterinaryMedicine,UniversityofMinnesota,2St.Paul,MN55108,DepartmentofVeterinaryMedicineandEpidemiology,SchoolofVeterinaryMedicine,UniversityofCalifornia,Davis,CA95616Lawsoniaintracellularisisthecausativeagentofp
4、rolifera-tiveenteropathy(PE),anemergingconcerninhorsesandanendemicdiseaseinpigs.EnterocytehyperplasiaisacommonlesioninPEbuttherearedifferencesregardingclinicalandpathologicalpresentationsamongaffectedspecies.WehypothesizethathostsusceptibilitytoLaw-soniain
5、fectiondependsonthespeciesoforiginoftheFigure1.FecalsheddingofLawsonia(blue-solidline¼porcineisolate-bacterialisolate.Theobjectiveofthisstudywastoevaluateinfectedanimals;red-dashedline¼equineisolate-infectedanimals).thesusceptibilitiesofhorsesandpigstoLaws
6、oniainfectionReferencesusingequineandporcineisolates.Twelve4-month-oldfoalsweredividedintothreegroups(n¼4/group)and[1]PusterlaN,etal.Oralinfectionofweanlingfoalswithanequineinfectedwithanequine[1]oraporcine[2]isolateandisolateofLawsoniaintracellularis,agen
7、tofequineproliferativeasalinesolution(negative-controlgroup).Anidenticalenteropathy.JVetInternMed2010;24:622.[2]GuedesRMC,etal.Onsetanddurationoffecalshedding,cell-medi-experimentaldesignwasappliedto183-week-oldpigsatedandhumoralimmuneresponsesinpigsafterc
8、hallengewithdividedintothreegroups(n¼6/group).TwopigsfromeachapathogenicisolateorattenuatedvaccinestrainofLawsoniaintra-groupwereeuthanized21dayspost-inoculation(PI)forcellularis.VetMicrobiol2003;91:135.evalu
