冠状病毒Coronavirusl论文-2010 Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication in a Lethal SARS-Cov Balb_C Mouse Model by.pdf

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1、A3623rdICARAbstractIssue/AntiviralResearch86(2010)A1–A78SIof100.TimeofadditionstudiesdemonstratedactivityofthishavedemonstratedthatCD4-BFFIdidnotactivatehumanwholecompoundwhenaddedaslateas16hafterviruschallengeofVerobloodorTcells,anditdidnotinterferewiththeco-

2、receptorcellswithanEC90of8.9g/ml.Significantimprovementinsurvival,functionofCD4inTlymphocytesinAPC-mediatedTcellactiva-serumlevelsofALT,andvirustiterintheliverwasobservedaftertions.bidtreatmentwith120mg/kg/dof2
-C-MeCfor7daysbeginningjustpriortoviruschallenge.

3、A4-daybidtreatmentregimenwithdoi:10.1016/j.antiviral.2010.02.381thisdosebeginning4hpriortoviruschallengewasalsoeffectiveinsignificantlyimprovingsurvival.Alowerdoseof80mg/kg/dwas72alsoeffectiveinsignificantlyimprovingsurvivalandserumALT.InhibitionofSevereAcuteRes

4、piratorySyndromeCoronavirusTreatmentwiththe120mg/kg/ddoseinitiatedbeginning2dpiwasReplicationinaLethalSARS-CovBalb/CMouseModelbyStingingeffectiveinsignificantlyimprovingsurvivalandserumALT.DuetoNettleLectin,UrticaDioicaAgglutinin(UDA)theseveregastrointestinalef

5、fectsassociatedwithlong-termtreat-ment,thiscompoundanditsderivativesmaynotbeclinicallyviableYohichiKumaki∗,MilesK.Wandersee,KevinW.Bailey,AaronJ.forthetreatmentofchronicHCV.Alternatively,short-termtreat-Smith,CraigW.Day,JasonR.Madson,DonaldF.Smee,DaleL.mentofa

6、nacuteflaviviraldiseaselikeYFVwouldlikelyminimizeorBarnardeliminatedeleterioussideeffectsassociatedwithlong-termtreat-
InstituteforAntiviralResearch,UtahStateUniversity,Logan,USAment,potentiallymakingtheuseof2-C-MeCandactivederivativesaviableoptionfortherapeuti

7、cintervention.Keywords:BALB/cmice;SARS-CoV;Urticadioicaagglutinin(UDA).Acknowledgement:[SupportedbyN01-AI-30048,N01-AI-30063(SouthernResearchInstitute)fromtheVirologyBranch,Urticadioicaagglutinin(UDA)wastestedforefficacyinalethalNIAID,NIH].SARS-CoV-infectedBALB

8、/cmousemodel.UDAisasmallplantmonomericlectin,8.7kDainsize,withanN-acetylglucosaminedoi:10.1016/j.antiviral.2010.02.380specificityandinhibitsvirusesfromNidoviralesinvitro.Inthecur-re