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1、The‘‘CommonCold”inFrailOlderPersons:ImpactofRhinovirusandCoronavirusinaSeniorDaycareCenterAnnR.Falsey,MD,*RobertM.McCann,MD,*William].Hall,MD,MaryM.Criddle,RN,“MariaA.Formica,MS,‘DennisWycofiLPN,‘JohnE.Kolassa,PhD+espiratorytractinfectionsarethesourceofsignificantOBJECTIVE:Toevaluate
2、theincidenceandimpactofrhino-Rmorbidityandmortalityinolderpersons.Viruses,suchvirusandcoronavirusinfectionsinolderpersonsattendingasinfluenzaandrespiratorysyncytialvirus(RSV),havebeendaycare.showntobethecauseofseriousdiseaseinthisagegroup.’DESIGN:Prospectivedescriptivestudy.Lessiskno
3、wnabouttheimpactofrhinovirusesandcorona-SETTLNG:ThreeseniordaycarecentersinRochester,Newviruses,thecausativeagentsinthemajorityof“commonYork.colds.’”Approximately20to40%ofupperrespiratorytractinfections(URIs)inadultsarecausedbyrhinoviruses,and5PATIENTS:Frailolderpersonsandstaffmember
4、softheto15%arecausedbycoronaviruses.Morethan100sero-daycarecenterswhodevelopedsignsorsymptomsofanacutetypesofrhinovirusesandtwomajorserotypesofcoronavirusrespiratoryillness(229EandOC43)havebeenider~tified.~-~ReinfectionswithMEASUREMENTS:Demographic,medical,andphysicalbothvirusesoccur
5、throughoutlife,inpartbecauseofmultiplefindingswererecordedonsubjectsatbaselineandduringserotypesandincompleteimmunity.‘-’Whiletheseinfec-respiratoryillness.Nasopharyngealspecimensforviralcul-tionsleadtosignificanttimelostfromworkandschool,theytureaswellasacuteandconvalescentseraforco
6、ronavirusgenerallydonotresultinseriousdiseaseinchildrenoryoung229Eenzymeimmunoassay(EIA)wereobtainedforallill-adults.”I2Ratesofacuterespiratorytractinfectionsdimin-nesses.ishwithadvancingage,mostlikelyasaresultoflessfrequentRESULTS:Duringthe44monthsofstudy,352olderpersonsexposure^.'^
7、However,frailolderpersonsattendingadultexperienced522illnesses.Thirty-five(7%)of522culturesdaycarecentersmayrepresentaspecialpopulationatin-werepositiveforrhinovirusand37(8%)of451serologiescreasedriskofinfectionandatriskforcomplicationsfromwerepositiveforcoronavirus229Einfection.Thec
8、linicalthese
