资源描述：
《冠状病毒Coronavirusl论文-1999 Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、AcluNeurolScand1999:100.-88-91Copvrinhr...Munkwmrd1999PrintedinUK.AllrightswsrnvdACTANEUROLOGICASCANDINAVICAISSN0001-6314CoronavirusesinspinalfluidofpatientswithacutemonosymptomaticopticneuritisDessauRB,LisbyG,FrederiksenJL.CoronavirusesinspinalfluidofR.
2、6.Dessau’,G.Lisby’,patientswithacutemonosymptomaticopticneuritis.J.L.Frederiksen’ActaNeurolScand1999:100:88-91.CMunksgaard1999.’DepartmentofClinicalMicrobiology,HerlevUniversityHospital,HerlevRingvej,DK-2720Acutemonosymptomaticopticneuritis(AMON)maybeani
3、nitialHerlev,Denmark;‘DepartmentofNeurology.symptomofmultiplesclerosis(MS).CoronaviruseshavebeenimplicatedGlostrupUniversityHospital,Ndr.Ringvej,DK-2600intheetiologyofMS.TheobjectiveofthepresentstudywastolookforGlostrup.DenmarkcoronaviralRNAinAMON,whichc
4、ouldbepresentintheinitialstagesofthedevelopmentofMS.Materialandmethods-Spinalfluidsfrom37patientswithAMONand15surgicalcontrolpatientswithprotrusionoftheintervertebraldiskwereassayedwithanestedmultiplexpolymerasechainreactionwithprimersspecificforhumancor
5、onavirusesstrain(HCV)229EandOC43.ResultsKeywords:humancoronavirus;opticneuritis;-Fourpatientsand1controlweremultiplesclerosis;polymerasechainreactionpositiveforHCV-229E.NoevidenceofHCV-OC43wasfound.Thefrequencyofpositivesampleswaslowandtherewasnostatisti
6、calR.B.Dessau,DeptofClinicalMicrobiology.AalborgdifferencebetweenAMONandcontrols.Conclusion~ThisstudydoesUniversityHospital,POBox365,DK-9000Aalborg.notprovideevidenceforanetiologicalroleofhumancoronavirusesinDenmarkacutemonosymptomaticopticneuritis.Accep
7、tedforpublicationMarch25,1999Acutemonosymptomaticopticneuritis(AMON)puncture.Thirty-foursampleswereobtainedfrom6mayoccurasanisolatedevent,butisoftento104days(median23days)aftertheonsetofconsideredaninitialsymptomofmultiplesclerosissymptoms.Threepatientsh
8、ad2attacksofAMON(MS).AbouthalfofthepatientswillconverttoandthesampleswereobtainedinrelationtothefirstclinicallydefiniteMSwithin15years(1).AMONepisode205,182and71daysbeforetheirsecondfrequentlylastsfromafewdaystoseveralweek
