冠状病毒Coronavirusl论文-1994 Immunity to transmissible gastroenteritis virus and porcine respiratory coronavirus infections in swine.pdf

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1、~:~Veterinary~'iimmunologyandimmunopathologyELSEV1ERVeterinaryImmunologyandImmunopathology43(1994)89-97ImmunitytotransmissiblegastroenteritisvirusandporcinerespiratorycoronavirusinfectionsinswineL.J.Sail'*,J.L.vanCott,T.A.BrimFoodAnimalHealthResearchProgram

2、,OhioAgriculturalResearchandDevelopmentCenter,TheOhioStateUniversity,Wooster,OH44691,USAAbstractDespitethepioneeringeffortstoidentifycorrelatesofpassiveimmunitytotransmissi-blegastroenteritisvirus(TGEV),effectivevaccinesforthecontrolofTGEinsucklingpigshaver

3、emainedelusive.TheinitialconceptofanenteromammaryimmunologicaxisinmonogastricsoriginatedfromstudiesoflactogenicimmunitytoTGEVinswine.ThesestudiesrevealedthatinfectionofpregnantswinewithvirulentTGEVstimulatedhighti-tersofSIgAantibodiesinmilkwhichcorrelatedwi

4、thprotectionofsucklingpigsagainstTGE;parenteralororalinoculationwithliveattenuatedorkilledTGEVvaccinesinducedmainlyIgGantibodiesinmilkwhichgenerallyprovidedpoorprotectiontosucklingpigs.TherecentappearanceofPRCVinfectionsinswineandcontinuingstudiesofTGEVin-f

5、ections,presentauniquemodelforfurtherstudiesofmucosalimmunity.Researchusingtheseviruseshasincreasedourunderstandingofthevariouscomponentsofthecommonmucosalimmunesystemandtheirinteractions.Althoughthemostimportantconsidera-tionindesigninganeffectivevaccinefo

6、rTGEVisthestimulationofGALTthroughintes-tinalvirusreplication,studiesaddressingthecontributionofBALTtoimmunitytoTGEVandPRCVmayprovideinsightsforalternativevaccineapproaches.ThemechanismbywhichexposuretoPRCVelicitsavariabledegreeofimmunitytoTGEVchallengeisun

7、-known.Virusreplicationinthegutorrespiratorytractisamajorfactoraffectingthemag-nitudeoftheimmuneresponseattherespectivesiteandmaybenecessaryfortherecruit-mentofspecificimmunecellsfromothermucosalinductivesites,i.e.,GALTtoBALTandBALTtoGALTmigration.Furtherst

8、udiesontheinductionandimmuneregulationofspecificresponsestoTGEVandPRCVthataffectthedistributionpatternsofIgM-,IgG-andIgA-antibody-secretingcells(ASC)andTlymphocytesshouldprovidevaluablein-sightsforopti