资源描述：
《心脏瓣膜置换术后动态监测血栓前体蛋白的临床价值分析.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、心脏瓣膜置换术后动态监测血栓前体蛋白的临床价值分析［摘要］目的动态监测分析血栓前体蛋白（Tp卩）对心脏瓣膜置换术后抗凝治疗及检测的临床价值。方法收集2012年5月〜2013年5月于本院开展心脏瓣膜置换术的40例患者为研究对象，将其随机均分为观察组和对照组，两组均于术前1d,术中（开放主动脉30min后），术后第2、3天检测各项指标，其屮对照组仅检测凝血酶原时间（PT）、国际标准化比值（TNR）,观察组同时检测Tp卩、PT和INR,比较两组的TNR和PT值,评价敏感性。结果两组术前1d,术中，术后第2、3天PT及INR
2、差异无统计学意义（P>0.05）。两组脑栓塞、轻度出血发生率差异无统计学意义（卩〉0.05）。心房颤动与窦性心律患者的INR比较，差异无统计学意义（P>0.05）,TpP比较，差异有统计学意义（P〈0.05）。结论TpP和INR等重耍抗凝指标虽不存在显著的相关性，但对其进行检测能够有效地指导开展抗凝治疗，特别是患者TpP值过低时，应该注意其出血威胁。［关键词］心脏瓣膜置换术；血栓前体蛋白；血栓形成；动态监测［中图分类号］R654.2：文献标识码］A［文章编号］1674-4721（2014）06（b）-0021-03C
3、linicalan且lysisofdynamicmonitoringthrombusprecursorproteinafterheartvalvereplacementDAIMinglLIQiu2WUJian-guolTANGKail1.DepartmentofCardiacSurgery,CentralPeople'sHospitalofZhanjiangCityinGuangdongProvince,Zhanjiang524037,China;2.ICUofCentralPeople'sHospitalofZha
4、njiangCityinGuangdongProvince,Zhanjiang524037,China[Abstract]ObjectiveToinvestigatetheclinicalvalueofdynamicmonitor!ngthrombusprecursorprotein(Tp卩)afterheartvalvereplacement.Methods40casesofpatientswithheartvalvereplacementinourhospitaifromMay2012toMay2013weres
5、eiectedastheresearchobjects,whowererandomlydividedintoobservationgroupandcontrolgroup,20casesineachgroup,theindexoftwogroups1dpreoperative,intra-operative(openaortic30min),eachpostoperative2d,3dweredetected,ofwhichonlytheprothrombintime(卩T),internationalstandar
6、dizationratio(TNR)wereexaminedincontrolgroup,atthesametime,theTpP,PTandINRwereexaminedinobservationgroup.TheINRandPToftwogroupswascompared.ResuItsThePTandTNRoftwogroups1dpreoperative,intra-operative,eachpostoperative2d,3dhadnosignificantdifferenee(P>0.05)•Thein
7、cidenceofcerebralembolismandmildbleedingoftwogroupshadnosignificantdifference(P>0.05)•TheINRofpatientswithatrialfibrillationandsinusrhythmhadnosignificantdifference(卩〉0.05)，buttheTp卩hadsignificanldifferenee(P<0.05)・ConclusionTheimportantindexesofTpPandINRdonoth
8、avesignificantcorrelation,buttheirexaminationcaneffectivelyguidetheanticoagulanttreatment‘especiallythosewhowiththeTpPvaluetoolow,thebleedingthreateningshouldbepaidattention
