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ID:51613817
大小:4.47 MB
页数:60页
时间:2020-03-26
《医药生技产业发展现况与趋势.ppt》由会员上传分享,免费在线阅读,更多相关内容在PPT专区-天天文库。
1、醫藥生技產業發展現況與趨勢講授大綱一、特性二、現況三、趨勢2一、特性3TheProductDevelopmentRoadmap4新藥研究開發與上市的流程圖5新藥研發平均成本增加圖Expenditures($million)6BiopharmaceuticalAttritionContinues…Source:Phrma2005Profile7TheValueLadderDevelopingBiotechProducts8摩根史坦利新藥價值鏈CalculatedValueofaHypotheticalNewDrugatV
2、ariousStagesofDrugDevelopmentbyDCFModelDevelopmentPhaseSuccessfulRatesCumulativeProbabilityEarlyPre-clinicalLate50%4%Pre-Clinical(IND)40%8%PhaseI73%19%PhaseII45%27%PhaseIII73%59%NDA81%81%Market100%100%Source:MorganStanleyResearch,10/15/029專業分工之概念PhaseIPhaseIIPha
3、seIII藥物探索臨床前試驗(動物試驗)Pre-ClinicalClinicalTrial(人體臨床試驗)量產INDNDA上市快速篩選藥物來源藥物改質藥物動力製造生產臨床試驗用藥品代工CROCMO藥理實驗毒理實驗試驗用動物先導工廠代理商行銷生物資訊化學合成TargetValidatedTargetLeadBPODrugDiscoveryDrugDevelopment上市後鑑測BPO:業務流程外包(BusinessProcessOutsourcing)資料來源:生技中心ITIS計畫整理10二、現況11BiotechInd
4、ex(BTK)outperformsNASDAQ&DJIAforthepastdecade12Significantcapitalflowsintobiotech/medicaldevicesectorssince200013WORLDWIDEGLOBALPHARMACEUTICALSALES14全球藥品市場15BurrillPublicBiotechCompanies2001to20061($billions)200120022003200420052006%CHANGE2005-2006Sales/Revenue
5、$39.0$42.7$47.4$59.5$71.5$82.615.5%R&DExpense12.313.514.316.818.521.717.3%NetIncome(loss)(4.7)(11.6)(4.1)(4.4)(4.1)(3.2)21.0%Cash&Equivalents245.341.941.645.547.751.47.7%MarketCapitalization3822243444004904920.4%NumberofCompanies356329315356363360-0.8%1IncludesA
6、DRs2IncludesmarketablesecuritiesSource:Burrill&Company16ThemappingofthehumangenomeandadvancesthatmakeitfasterandeasiertoscreenpotentialdrugcandidatesShouldbelightingafireunderdrugdevelopment,buttheyhaven’tsofar.July30,2007.BusinessWeek17學名藥(Generics)與生物相似性藥(Bios
7、imilar/Follow-onBiologics)市場18暢銷藥物專利到期公司產品主要適應症2005年銷售額專利到期PfizerZoloft憂鬱症332006Norvasc高血壓472007ZithromaxandZmax細菌感染202006Lipitor降膽固醇1302010Zyrtec/Cirrus過敏性鼻炎232007Merck&Co.Zocor降膽固醇442006Fosamax骨質疏鬆症322008Astra-ZenecaNexium胃潰瘍462005Toprol-XL/Seloken高血壓172007Eli
8、LillyZyprexa精神分裂症422011Glaxo-SmithKlineFlonase/Flixonase過敏性鼻炎122006Coreg高血壓102007Advair/Seretide氣喘552008Lamictal癲癇152008Lmitrex/Imigran偏頭痛132008Bristol-MyersSquibbPra
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