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1、奥扎格雷钠联合低分子肝索治疗不稳定型心绞痛45例疗效观察作者：许志强，于昆仑，张芳，史军彦单位：河北省河间市人民医院心内科，河北河间（）62450【摘要】目的：评价奥扎格雷钠联合低分子肝素治疗不稳定型心绞痛（UAP）的临床疗效及安全性。方法:将90例UAP患者随机分为对照组45例和治疗组45例,对照组给予常规治疗（包括硝酸脂类、&bela;受体阻滞剂、钙离子拈抗剂、他汀类调脂药、阿斯匹林等）加低分子肝素5000U每日二次，皮下注射，治疗纽•在此基础上加用奥扎格雷钠160mg溶于5%葡萄糖500ml,静脉滴注每日一•次，两组均连用10天，观察治疗
2、前后症状及心电图改善情况。结果：治疗后奥扎格雷纽有效率95.6%,对照纽有效率84.5%,两纽比较差异有统计学意义（PV0.05）；治疗纽心电图∑ST下降、∑T波倒置导联数、∑T波倒置深度均较对照纽明显改善（PV0.05）。结论:奥扎格雷钠联合低分子肝素治疗UAP疗效确切、安全。【关键词】奥扎格雷钠；低分子肝素；不稳定型心绞痛TheEffectsofOzagrelSodiumCombinedLowMolecularWeightHeparinin45PatientswithUnstableAnginaPectorisXUZ
3、hi-qiang,YUKun-lun,ZHANGFang,etalHejianPeople'sHospital,HebeiHejianO6245O,ChinaAbstract：Objective:ToevaluatetheeffectsandsafetyoftreatmentwithOzagrelsodiumcombinedlowmolecularweightheparin（LMWH）inpatientswithunstableanginapectoris（UAP）.Methods:NinetypatientswithUAPwereenroll
4、edandrandomlydeividedintotwogroups:controlgroupandtreatmentgroupieachgroupincludedfourty-fivepatients.Incontrolgroup,EachpatientwastreatedwithLMWH5000UiH,twiceadaybesidesnitrate,βreceptorblockers,calciumchannelblockers,aspirinandstatins.Intreatmentgroup,everypatientwasa
5、dministeredOzagrelsodium160nigsolved5%glucose500mlivdrop,onceadaybesidesthosedrugsusedincontrolgroup.Everypatientwasadministedcontinuelyfortendaysintwogroups.Theirsymptomsandthechangesofelectrocardiogram（ECG）wererecordedandcomparedbetweentwogroupsaftertendaystreatment.Result
6、s:TheeffectiverateoftreatmentwithOzagrelsodiumcombinedLMWHintreatmentgroupis95.6%,whiletheeffectiverateoftreatmentwithLMWHonlyincontrolgroupis84.5%.Thereisansignificantdifferencebetweentwogroups（P<0.05）.Intreatmentgroup,thedegreesof∑ST-segmentdepression,theleadnumbersof&
7、sum;Twaveinvertionandthedegreesof∑Twaveinvertionaresignificantlyimprovedcomparedwiththoseincontrolgroup/allP<0.05）.Conclusion:InpatientswithUAP,treatmentwithOzagrelsodiumcombinedLMWHiseffectiveandsafety.Keywords:Ozagrelsodium；Lowmolecularweightheparin：Unstableanginapecto
8、ris奥扎格雷钠目前临床主要应用于缺血性脑血管病的治疗，为了观察其对不稳定型心绞痛（UAP）的疗效及不良反应，我们対2006年3月至2007年10月在
