脑益智方联合康复训练治疗肌张力低下型脑性瘫痪临床观察.doc

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1、脑益智方联合康复训练治疗肌张力低下型脑性瘫痪临床观察孙进王君林晓芬谢冰伍芳湖北省恩施州中心医院康复医学科摘要：冃的：观察醒脑益智方联合康复训练治疗肌张力低下型脑性瘫痪的临床疗效，并分析其机制。方法:随机选取于2014年1月至2015年12月恩施州中心医院康复门诊及住院的才岁肌张力低下型脑性瘫痪患儿120例，按随机数字表法随机分为观察组和康复组，每组60例，同时选取20例同期同院体检科体检的正常健康患儿作为对照组。康复组予以康复训练，观察组予以康复训练结合醒脑益智方治疗。同时对各组患者进行的GMFM量表的评估，测定其肌力

2、的变化，并抽取血液测定转化生长因子B1和BDNF,比较各组数据的统计差异并分析其临床疗效。结果:经治疗后，观察组与康复组治疗后的GMFM、肌力与TGF-(31均较治疗前明显提高(P<0.05),BDNF降低(P<0.05)，且观察组治疗后与对照组比较较，差异无统计学意义(P>0.05)。结论:醒脑益智方联合康复训练可以有效改善治疗肌张力低下型脑性瘫痪临床症状，改善其肌力，提高患儿的生活能力水平，值得推广使用。关键词：醒脑益智方;肌张力低下型;脑性瘫痪;神经重塑;转化牛长因了01;作者简介：孙进(1985.08-),男，

3、本科，住院医师，研究方向：中西医结合治疗神经内、外科脑出血、脑梗死等，E-mai1:ml3872713536_1@163.com收稿日期:2017-07-05基金：湖北省卫生和计划生育委员会科研项目(WJ2015MB115)EffectsofXingnaoYizhiFangCombinedwithRehabilitationTrainingonChildrenwithCerebralPalsyDuetoDystoniaanditsEffectonTransformingGrowthFactorBeta1andNerve

4、RemodelinginChildrenSunJinWan£JunLinXiaofenXieBingWuFangDepartmentofRehabilitotionandMedicine,TheCentralHospitalofEnshiPrefecture,HubeiProucnce;Abstract：Objective:Toobservetheclinicalcura.tiveeffectofXingnaoYizhiFangcombinedwithrehabi1itationtraininginthetreatme

5、ntofatoniccerebralpalsy,andtoanalyzeitsmechanism.Methods:Atotalof120casesofchildrenwithcerebralpalsyduetodystoniaaging2-6yearsoldwhoweretreatedinoutpatientdepartmentandhospitalizationdepartmentinourhospitolfromJanuary2014toDecember2015wereseiectedanddividedintot

6、reatmentgroupandrehabilitationgroupwith60casesineach.And20casesofhealthychildrenfromphysicalexaminationdepartmentofourhospitalwereselectedascontrolgroup.Therehabilitationgroupwasgivenrehabilitationtraining,andthetreatmentgroupwasgivenrehabilitationtrainingcombin

7、edwithXingnaoYizhidecoction.Atthesametime,theGMFMscaleofeachgroupwasevaluated,andthechangesofmusclestrengthweremeasured.ThebloodsamplesweretakentodetermineTGF-beta1andBDNF.Thestatisticaldifferenceofeachgroup"sdatawasanalyzedandtheclinicalefficacywasalsoanalyzed.

8、Results:Aftertreatment,GMFM,musclestrengthandTGF-beta1wereofthetreatmentgroupandrehabilitationgroupaftertreatmentweresignificantlyincreased(P<0.05),andBDNFwasdecrease