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1、王洪静1周雪艳2(1•大庆龙南医院干部病房,黑龙江大庆1634532.吉林大学中日联谊医院心内科,吉林长春130031)[摘要]目的:探讨应用血管紧张素转换酶抑制剂治疗房颤的临床意义;方法:60例房颤患者随机分为2组,1组常规治疗设为对照组,1组在给予常规治疗的基础上加用ACEI类药物(洛汀新)设为治疗组,观测两组房颤患者的转复成功率、房颤复发率、左心功能EF%、左房大小,血管紧张素II水平(Angll),心电图ST段改变,随访6个月,结果:治疗组较对照组Angll浓度降低,房颤转复成功率高,复发率低、左心房缩小,半年后发生心功能不全的比
2、例均较对照组低。结论:房颤患者早期应用血管紧张素转换酶抑制剂,可能改善房颤的转律效果及抑制心房重构,改善心功能。[关键词]心房颤动肾素-血管紧张素-醛固酮系统血管紧张素转换酶抑制剂盐酸贝那普利[中图分类号]R541.75[文献标识码]BTheclinicalresearchofBenazeprilhydrochloride(1otensin)totreatatrialfibrillationWANGHong-jing1,ZHOUXue-yan2(1.DepartmentofCadreWard,Longnanhospita1,Daqingl
3、63453,China;2.DepartmentofCardiovascula-rChina-JapanUnionHospital,JilinUniversity,Changchun130031,China)Abstract:ObjectiveTodiscussvasculartensionpigmentconversionenzymeinhibitortreatmentatrialfibri1lationofclinicalsignifiesnee.Method:60casesatrialfibrillationpatientsrand
4、omisdividedinto2group,1GroupGeneraltreatmentsetforcontrolledgroup,1groupinregulartreatmentonthebasisoftheadditionalapplicationofACEIdrug(lotensin)issettothetreatmentgroup,observationtwogroupatrialfibrillationpatientsofcardioversionsuccessrate,andatrialfibrillationrecurren
5、cerate,andleftheartfunctionEF%,andleftatrialsize,vasculartensionpigment11level(AnglI),ECGSTsegmentchange,follow-up6months・ResuIts:TreatmentgroupcomparedwithcontrolgroupsAnglIconcentrationreduced,atrialfibrillationcardioversionsuccessrateishigh,lowrecurrencerate,Leftatrial
6、lessen,sixmonthsaftercardiacinsufficiencyoftheratioislowerthanthecontrolgroup・Conclusion:Atrialfibrillationinpatientswithearlyuseofangiotensin-convertingenzymeinhibitor,mayimprovethetransferlegaleffectandsuppressionofatrialfibrillationatrialremodeling,improvingcardiacfunc
7、tion.KeyWord:Atrialfibrillation;renin-angiotensin-aldosteronesystem;angiotensin-convertingenzymeinhibitors;Benazeprilhydrochloride心房颤动(atrialfibrillation,AF)是临床上最常见的心律失常,但有关房颤的发生机制至今尚未阐明。随着研究的深入,越来越多的证据表明心房电重构和结构重构是房颤发生和维扌寺过程中的关键环节,心房结构重构的影响尤为重要。本文探讨房颤患者应用血管紧张素转换酶抑制剂(盐酸贝那
8、普利Benazepri1Hydrochloride,商品名:洛汀新)抑制肾素-血管紧张素-醛固酮系统,对房颤患者复律、维持窦律及对心功能的保护作用。1.资料及方法1.1对象研究对象选择自200