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时间:2020-03-21
《糖尿病肾损害的评价指标.pdf》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、24·论著·May2014,Vo1.12,No.13糖尿病肾损害的评价指标杜婧张悦魏枫薛晔霞(包头医学院第一附属医院内分泌科,内蒙古包头014010)【摘要】目的探讨联合检测血清胱抑素C(CysC)及尿微量白蛋白/肌酐(A/C)在评估糖尿病早期肾损害中的诊断价值。方法选取2008年6月至2011年l2月间包头一附院收治的220例2型糖尿病(DM2)患者,根据尿白蛋白排泄率(UAER)分为三组:DM组,DN1组、DN2组,同时选择同期我院健康体检者75例作为正常对照组(NC组),同时检测血CysC及尿A/C,对检测结果行统计学分析。结果与NC组比较,其余
2、实验组血CysC及尿A/C均升高,有统计学差异<0:05),且DN2组血CysC及尿A/C明显高于DN1组(P3、ing,zHANGYue,WEIFeng,XUEYe-xia(DepartmentofEndocrinology,TheFirstAfiliatedHospitalofBaotouMedicalCollege,Baotao014014Chin【Abstract】ObjeetlveTostudythediagnosticvalueofserumcystatinC(CysC)andmicroalburninuria/creatinine(A/C)combineddetectioninthediagnosisofearlyrenaldamagewithdia4、betespatients.Methods220casespatientswithdiabetesmellituswhovisitedFirstaffiliatedhospitalofBaotoumedicalcollege(between2008-06and2011-12)wereenrolled,TheyweredividedintoDMgroup,DN1groupandDN2groupaccordingtourinaryalbuminexcretionrate(UAER).And75casesofhealthypeoplewereusedasno5、rmalgroup(NCgroup).CysCandurineA/Cworedetected.ResultsTheserumCysCandurineA/CofothergroupswerehighercomparedwithNCgroup(P<0.05),andgroupDN2werehigherthangroupDN1(P<0.05).ThecombineddetectionofeachindexCanimprovedthepositiverate,andtwoindexeshadsignificantlypositivecorrelations.C6、onclusionInadditiontotheindexofearlydiabeticrenaldamageurineA/Cwhichwascurrentlyaccepted.Theserur~CysCalsoCanbeusedassensitiveindicatorsofearlyrenaldamageofdiabetes,andcombineddetectionhashigherclinicalvalue.IKeywordslDiabeticNephropathy;Serumcystatin;UrineC近年来随着生活水平的提高,糖尿病的发病率逐7、渐上升,糖尿病各组患者均清晨空腹采血3mL,同时留取晨新鲜中段尿10mL,肾病是糖尿病严重的并发症之一,已成为西方国家终末期糖尿病肾病3000转/分离b5min取上清液待检,血CysC采用颗粒增强免疫散射比的主要原因】,糖尿病肾损害早期虽逆转但临床症状不显著,易错失浊法,尿微量白蛋白采用速率散射比浊法,试剂均由上海德波生物有诊治的最佳时期而进展为终末期肾病,因此选择合适的指标评价糖尿限公司提供,为减少尿液浓缩及稀释可能造成结果误差,尿微量白蛋病早期肾损害是临床工作中的迫切需求。本文旨在探讨血CysC及尿白均用尿肌酐矫正,即尿A/C。A/C联合检测在糖尿8、病早期肾损伤中的诊断意义。1.4统计学方法1资料与方法采用SPSS13.0软件进行统计处理,计
3、ing,zHANGYue,WEIFeng,XUEYe-xia(DepartmentofEndocrinology,TheFirstAfiliatedHospitalofBaotouMedicalCollege,Baotao014014Chin【Abstract】ObjeetlveTostudythediagnosticvalueofserumcystatinC(CysC)andmicroalburninuria/creatinine(A/C)combineddetectioninthediagnosisofearlyrenaldamagewithdia
4、betespatients.Methods220casespatientswithdiabetesmellituswhovisitedFirstaffiliatedhospitalofBaotoumedicalcollege(between2008-06and2011-12)wereenrolled,TheyweredividedintoDMgroup,DN1groupandDN2groupaccordingtourinaryalbuminexcretionrate(UAER).And75casesofhealthypeoplewereusedasno
5、rmalgroup(NCgroup).CysCandurineA/Cworedetected.ResultsTheserumCysCandurineA/CofothergroupswerehighercomparedwithNCgroup(P<0.05),andgroupDN2werehigherthangroupDN1(P<0.05).ThecombineddetectionofeachindexCanimprovedthepositiverate,andtwoindexeshadsignificantlypositivecorrelations.C
6、onclusionInadditiontotheindexofearlydiabeticrenaldamageurineA/Cwhichwascurrentlyaccepted.Theserur~CysCalsoCanbeusedassensitiveindicatorsofearlyrenaldamageofdiabetes,andcombineddetectionhashigherclinicalvalue.IKeywordslDiabeticNephropathy;Serumcystatin;UrineC近年来随着生活水平的提高,糖尿病的发病率逐
7、渐上升,糖尿病各组患者均清晨空腹采血3mL,同时留取晨新鲜中段尿10mL,肾病是糖尿病严重的并发症之一,已成为西方国家终末期糖尿病肾病3000转/分离b5min取上清液待检,血CysC采用颗粒增强免疫散射比的主要原因】,糖尿病肾损害早期虽逆转但临床症状不显著,易错失浊法,尿微量白蛋白采用速率散射比浊法,试剂均由上海德波生物有诊治的最佳时期而进展为终末期肾病,因此选择合适的指标评价糖尿限公司提供,为减少尿液浓缩及稀释可能造成结果误差,尿微量白蛋病早期肾损害是临床工作中的迫切需求。本文旨在探讨血CysC及尿白均用尿肌酐矫正,即尿A/C。A/C联合检测在糖尿
8、病早期肾损伤中的诊断意义。1.4统计学方法1资料与方法采用SPSS13.0软件进行统计处理,计
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