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ID:50723260
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页数:22页
时间:2020-03-16
《针对癌症的抗体治疗 Antibody therapy of cancer (2).ppt》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、AntibodytherapyofcancerMajorPointsMechanismsoftumorcellkillingThecharacteristicsanidealtargetantigenshouldhaveDevelopmentofantibodiesfortheclinicCancerserologyDiscoveryofCEAandα-fetoproteinEmergencyofcytotoxictesttoanalysethecellsurfacereactivityofalloantibodiesDevelopmentofhybridomatec
2、hnologyandfluorescence-activatedcellsorting(FACS)mAbsTumourstromalandtumourvascularcellsexpressnovelantigensMultipleApproachesforAntibodyConstructionMechanismsoftumorcellkillingdirectactionoftheantibodyimmune-mediatedcellkillingmechanismsspecificeffectsofanantibodyontumourvasculatureands
3、tromaMechanismsoftumorcellkilling1.Directactionoftheantibodyreceptorblockadeoragonistinductionofapoptosisdeliveryofadrugorcytotoxicagent1.DirectactionoftheantibodyLeadtoapoptosisReducedproliferationandapoptosisNeutralizationDeliverapayloadMechanismsoftumorcellkilling2.Immune-mediatedcell
4、killingmechanismscomplement-dependentcytotoxicityADCCregulationofTcellfunctionopsonizationCDC3.SpecificeffectsontumorvasculatureandstromaMechanismsoftumorcellkillingInductionofeffectorfunctionprimarilythroughADCCImmunemodulationofTcellfunctionMostSuccessful!Tumourantigensasantibodytarget
5、sThesafetyandefficacyofmAbsindependonTHENATUREoftargetantigens.TumourantigensasantibodytargetsIdealtargetantigenSHOULDBE1.Abundantandaccessible2.Expressedhomogeneously,consistentlyandexclusively3.MinimalsecretionAssecretedantigenscanbindtheantibodyinthecirculationandcouldpreventsufficien
6、tantibodyfrombindingtothetumour.4.NotberapidlyinternalizedIfthemechanismofactionisADCCorCDC,soastomaximizetheavailabilityoftheFcregiontoimmuneeffectorcellsandcomplementproteins.5.GoodinternalizationDelivertoxinsintothecancercell.TumourantigensasantibodytargetsSeveraldifferentcategoriesHe
7、matopoieticdifferentiationantigensCellsurfacedifferentiationantigensTumourantigensasantibodytargetsInanotherwayAntigensthatareinvolvedingrowthanddifferentiationsignallingCEAEGFRAntigensinvolvedinangiogenesisproteinsorgrowthfactorsthatsupporttheformationofnewmicrovasculatu
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