资源描述：
《the role of statins in cancer therapy论文》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、TheRoleofStatinsinCancerTherapy论文.freelor,#8226;,Chemotherapy,#8226;,Inflammation,#8226;,.freelentofhypercholesterolemia,maybeapplicabletocancerprevention.Discusshoedicine.ABSTRACTAdministrationof3-hydroxy-3-methylglutarylcoenzymeAreductaseinhibitors,orstatins,toambulatorypatientsisassociated
2、adversecardiovascularevents,includingdeath,myocardialinfarction,stroke,atrialfibrillation,andrenaldysfunction.Hocholesterollevels,mayalsoplayapotentialroleinthepreventionandtreatmentofcancer.Specifically,statinshavebeenshoorgroetastasis.Thefeasibilityandefficacyofstatinsforthepreventionandtre
3、atmentofcancerisrevieethylglutarylcoenzymeA(HMG-CoA)reductaseinhibitors,orstatins,aremonly-useddrugsforthetreatmentofhypercholesterolemia1,2.Statinsdecreaseloevalonateandistherate-limitingstepinhepaticcholesterolbiosynthesis3.Clinically,statintreatmentisassociatedationandastabilizationofpre-e
4、xisting"vulnerable"atheroscleroticplaques4.Moreover,statinshavebeenshoyocardialinfarction,stroke,atrialfibrillation,andrenaldysfunctioninambulatorypatientpopulations2,513.Statinadministrationisalsoassociatedinalcoronaryangioplasty9andcardiac14,15,vascular1618,andnoncardiovascular19surgery.Hoi
5、tedtopatientsia.SeveralrandomizedclinicaltrialshaveshoaltotalandLDLcholesterollevels,statinadministrationisassociatedorbidityandmortality7,8.Statinsthusexertpleiotropiceffectsindependentoftheireffectsoncholesterol20.AlthoughtheexactmechanismsbyetaboliteofHMG-CoAreductase,mevalonicacid,isaprec
6、ursorofcholesterolandtheisoprenoidintermediatesfarnesylandgeranyl-geranylpyrophosphate.Theseintermediatesareessentialforthepost-translationalmodificationofintracellularG-proteins,suchasRho,Rac,andRas,thatregulateendothelial,platelet,andleukocytefunction2123.Statinshavealsobeenshoodulatevascul
7、arremodelingbyinhibitingcellularmatrixmetalloproteinasesandtranscriptionfactors,suchasnuclearfactor-B23.Inpatientsesoridiopathicdilatedcardiomyopathy,statintherapyhasbeenshomatoryactivity,includingchangesinC-reactiveprotein(CRP),serumamyloidA
